Книга: Тело может! Как контролировать, лечить и предотвращать рак
Назад: Благодарности
Дальше: Примечания

Источники

Введение. Раковый кризис

1. Akulapalli Sudhakar. “History of Cancer, Ancient and Modern Treatment Methods“, Journal of Cancer Science and Therapy 1, no. 2 (December 1, 2009): 1–4, doi:10.4172/1948-5956.100000e2.

2. N. Howlader et al., eds., “SEER Cancer Statistics Review, 1975–2011“, National Cancer Institute, Bethesda, MD, last updated December 17, 2014, http://seer.cancer.gov/csr/1975_2011. Based on November 2013 SEER data.

3. M. C. King, J. H. Marks, and J. B. Mandell, “Breast and Ovarian Cancer Risks Due to Inherited Mutations in BRCA1 and BRCA2,” Science 302, no. 5645 (October 24, 2003):643–46, doi:10.1126/science.1088759.

4. J. J. Mangano, “A Rise in the Incidence of Childhood Cancer in the United States,” International Journal of Health Services 29, no. 2 (1999): 393–408, https://www.ncbi.nlm.nih.gov/pubmed/10379458.

5. Melissa Jenco, “AAP Responds to Study Showing Link between Cell Phone Radiation, Tumors in Rats,” AAP News, May 27, 2016, http://www. aappublications.org/news/2016/05/27/Cancer052716.

6. Dave Levitan, “Adolescent / Young Adult Cancer Survivors Have Significantly Increased CVD Risk,” Cancer Network, March 10, 2016, http:// www.cancernetwork.com/cancer-complications/adolescent-young-adult-cancer-survivors-have-significantly-increased-cvd-risk.

7. Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar, Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal, “Cancer Is a Preventable Disease That Requires Major Lifestyle Changes,” Pharmaceutical Research 25, no. 9 (September 2008): 2097–116, doi:10.1007/s11095-008-9661-9.

8. Neil McKinney, Naturopathic Oncology: An Encyclopedic Guide for Patients and Physicians (Victoria, Canada: Liaison Press, 2016).

9. Douglas Hanahan and Robert A. Weinberg, “Hallmarks of Cancer: The Next Generation,” Cell 144, no. 5 (March 4, 2011): 646–74, doi:10.1016/j. cell.2011.02.013.

10. Timothy J. Key, Arthur Schatzkin, Walter C. Willett, Naomi E. Allen, Elizabeth A. Spencer, and Rith C. Travis, “Diet, Nutrition and the Prevention of Cancer,” Public Health Nutrition 7, no. 1A (February 2004): 187–200, doi:10.1079/PHN2003588.

11. Mei-Sing Ong and Kenneth D. Mandi, “New Guidelines for Breast Cancer Screening,” Health Affairs 35, no. 1 (January 2016): 180, doi:10.1377/ hlthaff.2015.1513.

12. “Developments in Cancer Treatments, Market Dynamics, Patient Access and Value: Global Oncology Trend Report 2015,” QuintilesIMS Institute, http://www.imshealth.com/en/thought-leadership/quintilesims-institute/ reports/global-oncology-trend-2015.

13. K. Robin Yabroff, Emily C. Dowling, Gery P. Guy, Matthew P. Banegas, Amy Davidoff, Xuesong Han, Katherine S. Virgo, et al., “Financial Hardship Associated with Cancer in the United States: Findings from a Population-Based Sample of Adult Cancer Survivors,” Journal of Clinical Oncology 34, no. 3 (January 20, 2016): 259–67, doi:10.1200/JCO.2015.62.0468.

14. “FDA News Release: FDA Commissioner Announces Avastin Decision,” US Food and Drug Administration, November 18, 2011, last updated March 12, 2014, http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ ucm280536.htm.

15. Vishal Ranpura, Sanjaykumar Hapani, and Shenhong Wu, “Treatment-Related Mortality with Bevacizumab in Cancer Patients,” JAMA 305, no. 5 (February 3, 2011): 487–94, doi:10.1001/jama.2011.51.

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Глава 1. Метаболический подход

1. Bharat B.Aggarwal and Shishir Shishodia, “Molecular Targets of Dietary Agents for Prevention and Therapy of Cancer,” Biochemical Pharmacology 71, no. 10 (May 14, 2006): 1397–421, doi:10.1016/j.bcp.2006.02.009.

2. Keith I. Block, Charlotte Gyllenhaal, Leroy Lowe, Amedeo Amedei, A. R. M. Ruhul Amin, Amr Amin, Katia Aquilano, et al., “Designing a BroadSpectrum Integrative Approach for Cancer Prevention and Treatment,” Seminars in Cancer Biology 35, supplement (December 2015): s276–304, doi:10.1016/j.semcancer.2015.09.007.

3. Song Wu, Scott Powers, Wei Zhu, and Yusuf A. Hannun, “Substantial Contribution of Extrinsic Risk Factors to Cancer Development,” Nature 529, no. 7584 (January 7, 2016): 43–47, doi:10.1038/nature16166.

4. Soroush Niknamian, Vahid Hosseini Djenab, Sora Niknamian, and Mina Nazari Kamal, “The Prime Cause, Prevention and Treatment of Cancer,” International Science and Investigation Journal 5, no. 5 (December 2016): 102–24, http://isijournal.info/journals/index.php/ISIJ/article/view/246.

Глава 3. Генетика, эпигенетика и нутригеномика

1. D. P. Labbé, G. Zadra, E. M. Ebot, L. A. Mucci, P. W. Kantoff, M. Loda, and M. Brown, “Role of Diet in Prostate Cancer: The Epigenetic Link,” Oncogene 34, no. 36 (September 3, 2015): 4683–91, doi:10.1038/onc.2014.422.

2. Preetha Anand, Ajaikumar B. Kunnumakara, Chitra Sundaram, Kuzhuvelil B. Harikumar, Sheeja T. Tharakan, Oiki S. Lai, Bokyung Sung, and Bharat B. Aggarwal, “Cancer Is a Preventable Disease That Requires Major Lifestyle Changes,” Pharmaceutical Research 25, no. 9 (September 2008): 2097– 116, doi:10.1007/s11095-008-9661-9; Thomas N. Seyfried, Roberto E. Flores, Angela M. Poff, and Dominic P. D'Agostino, “Cancer as a Metabolic Disease: Implications for Novel Therapeutics,” Carcinogenesis 35, no. 3 (December 2013): 515–27, doi:10.1093/carcin/bgt480.

3. Gordana Supic, Maja Jagodic, and Zvonko Magic, “Epigenetics: A New Link between Nutrition and Cancer,” Nutrition and Cancer 65, no. 6 (August 2, 2013): 781–92, doi:10.1080 /01635581.2013.805794.

4. NIH, “What Are Single Nucleotide Polymorphisms (SNPs)?” Genetics Home Reference, https://ghr.nlm.nih.gov/primer/genomicresearch/snp.

5. Mojgan Hosseini, Massoud Houshmand, and Ahmad Ebrahimi, “MTHFR Polymorphisms and Breast Cancer Risk,” Archives of Medical Science 7, no. 1 (February 2011): 134–37, doi:10.5114/aoms.2011.20618.

6. Hannah Landecker, “Food as Exposure: Nutritional Epigenetics and the New Metabolism,” Biosocieties 6, no. 2 (June 2011): 167–94, doi:10.1057/ biosoc.2011.1.

7. Cindy D. Davis and Eric O. Uthus, “DNA Methylation, Cancer Susceptibility, and Nutrient Interactions,” Experimental Biology and Medicine 229 (November 2004): 988–95, http://journals.sagepub.com/doi/ abs/10.1177/153537020422901002.

8. Maddalena Rossi, Alberto Amaretti, and Stefano Raimondi, “Folate Production by Probiotic Bacteria,” Nutrients 3, no.1 (January 2011): 118–34, doi:10.3390/nu3010118.

9. D. P. Bezerra, J. F. Marinho Filho, A. P. Alves, C. Pessoa, M. O. de Moraes, O. D. Pessoa, M. C. Torres, E. R. Silveira, F. A. Viana, and L. V. Costa-Lotufo, “Antitumor Activity of the Essential Oil from the Leaves of Croton regelianus and Its Component Ascaridole,” Chemistry and Biodiversity 6, no. 8 (August 2009): 1224–31, doi:10.1002/cbdv.200800253.

10. Edith Perez and Joanne Mortimer, Journal of Clinical Oncology 32, no. 30 (October 20, 2014).

11. Benjamin F. Voight, Sridhar Kudaravalli, Xiaoquan Wen, and Jonathan K. Pritchard, “A Map of Recent Positive Selection in the Human Genome,” PLOS Biology 4, no. 3 (March 7, 2006): 446–58, doi:10.1371/journal.pbio.0040072.

12. Daniel Lieberma, The Story of the Human Body: Evolution, Health, and Disease (New York: Pantheon Books, 2013).

13. Jared M. Diamond, Guns, Germs, and Steel (New York: Spark Publications, 2003).

14. The Norwegian University of Science and Technology (NTNU), “Feed Your Genes: How Our Genes Respond to the Foods We Eat,” ScienceDaily, September 20, 2011, http://www.sciencedaily.com/ releases/2011/09/110919073845.htm.

15. Angela Harras, Cancer Rates and Risks, 4th ed. (Washington, DC: National Institutes of Health, 1996), NIH Publication no. 96-691.

16. Patrick J. Stover, “Influence of Human Genetic Variation on Nutritional Requirements,” American Journal of Clinical Nutrition 83, no. 2, supplement (February 2006): 436s–42.

17. M. Lorenzi, D. F. Montisano, S. Toledo, A. Barrieux, “High Glucose Induces DNA Damage in Cultured Human Endothelial Cells,” Journal of Clinical Investigation 77, no. 1 (January 1986): 322–25, doi:10.1172/JCI112295.

18. Haibo Liu and Anthony P. Heaney, “Refined Fructose and Cancer,” Expert Opinion on Therapeutic Targets 15, no. 9 (September 2011): 1049–59, doi:10.1517/14728222.2011.588208; Eiji Furuta, Hiroshi Okuda, Aya Kobayashi, and Kounosuke Watabe, “Metabolic Genes in Cancer: Their Roles in Tumor Progression and Clinical Implications,”Biochimica et biophysica acta (BBA) 1805, no. 2 (April 2010): 141–52, doi:10.1016/j.bbcan.2010.01.005.

19. Ali M.Ardekani and Sepideh Jabbari, “Nutrigenomics and Cancer,” Avicenna Journal of Medical Biotechnology 1, no. 1 (April – June 2009): 9–17, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3558114.

20. Gray Graham, Deborah Kesten, and Larry Scherwitz, Pottenger's Prophecy: How Food Resets Genes for Wellness or Illness (Amherst, MA: White River Press, 2011).

21. Gijs A. Kleter, Ad A. C. M. Peijnenburg, and Henk J. M. Aarts, “Health Considerations Regarding Horizontal Transfer of Microbial Transgenes Present in Genetically Modified Crops,” Journal of Biomedicine and Biotechnology 2005, no. 4 (2005): 326–52, doi:10.1155/jbb.2005.326.

22. “New Cancer Cases Rise Globally, but Death Rates Are Declining in Many Countries,” Institute for Health Metrics and Evaluation, accessed November 3, 2016, http://www.healthdata.org/news-release/new-cancer-cases-rise-globally-death-rates-are-declining-many-countries.

23. Anthony Samsel and Stephanie Seneff, “Glyphosate, Pathways to Modern Diseases II: Celiac Sprue and Gluten Intolerance,” Interdisciplinary Toxicology 6, no. 4 (December 2013): 159–84, doi:10.2478/intox-2013-0026.

24. Leah Schinasi and Maria E. Leon, “Non-Hodgkin Lymphoma and Occupational Exposure to Agricultural Pesticide Chemical Groups and Active Ingredients: A Systematic Review and Meta-Analysis,” International Journal of Environmental Research and Public Health 11, no.4 (April 23, 2014): 4449–527, doi:10.3390/ijerph110404449.

25. Sándor Spisák, Norbert Solymosi, Péter Ittzés, András Bodor, Dániel Kondor, Gabor Vattay, Barbara K. Barták, et al., “Complete Genes May Pass from Food to Human Blood,” PLOS ONE 8, no. 7 (July 30, 2013): e69805, doi:10.1371/journal.pone.0069805.

26. Chris D. Meletis and Kimberly Wilkes, “Mitochondria: Overlooking These Small Organelles Can Have Huge Clinical Consequences in Treating Virtually Every Disease,” Townsend Letter, June 2015, http://www. townsendletter.com/June2015/mito0615.html.

27. “GM Crops List,” International Service for the Acquisition of AgriBiotech Applications, accessed November 3, 2016, http://www.isaaa.org/gmapprovaldatabase/cropslist.

28. Kelsey L. Tinkum, Kristina M. Stemler, Lynn S. White, Andrew J. Loza, Sabrina Jeter-Jones, Basia M. Michalski, Catherine Kuzmicki, et al., “Fasting Protects Mice from Lethal DNA Damage by Promoting Small Intestinal Epithelial Stem Cell Survival,” Proceedings of the National Academy of Sciences of the United States of America 112, no. 51 (December 22, 2015): e7148–54, doi:10.1073/pnas.1509249112.

29. Michael T. Murray, How to Prevent and Treat Cancer with Natural Medicine (New York: Riverhead Books, 2002).

30. Kumar S. D. Kothapalli, Kaixiong Ye, Maithili S. Gadgil, Susan E. Carlson, Kimberly O. O'Brien, Ji Yao Zhang, Hui Gyu Park, et al., “Positive Selection on a Regulatory Insertion-Deletion Polymorphism in FADS2 Influences Apparent Endogenous Synthesis of Arachidonic Acid,” Molecular Biology and Evolution 33, no. 7 (July 2016): 1726–39, doi:10.1093/molbev/ msw049.

31. Rima Obeid, “The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway,” Nutrients 5, no. 9 (September 9, 2013): 3481–95, doi:10.3390/nu5093481.

32. Stuart A. S. Craig, “Betaine in Human Nutrition,” American Journal of Clinical Nutrition 80, no. 3 (September 2004): 539–49, http://ajcn.nutrition. org/content/80/3/539.full.

33. H. Pellanda, “Betaine Homocysteine Methyltransferase (BHMT)– Dependent Remethylation Pathway in Human Healthy and Tumoral Liver,” Clinical Chemistry and Laboratory Medicine 51, no. 3 (March 1, 2013): 617–21, doi:10.1515/cclm-2012-0689.

34. Ana Lúcia Vargas Arigony, Iuri Marques de Oliveira, Miriana Machado, Diana Lilian Bordin, Lothar Bergter, Daniel Prá, and Joêo Antonio Pкgas Henriques, “The Influence of Micronutrients in Cell Culture: A Reflection on Viability and Genomic Stability,”BioMed Research International 2013 (May 2013): 1–22, doi:10.1155/2013/597282.

35. Keith Block, C. Gyllenhaal, L. Lowe, A. Amedei, A. R. Amin, A. Amin, K. Aquillano, et al., “Designing a Broad-Spectrum Integrative Approach for Cancer Prevention and Treatment.” Seminars in Cancer Biology 35, supplement (December 2015): s276–304, doi:10.1016/j.semcancer.2015.09.007.

36. Avinash M. Topè and Phyllis F. Rogers, “Evaluation of Protective Effects of Sulforaphane on DNA Damage Caused by Exposure to Low Levels of Pesticide Mixture Using Comet Assay,” Journal of Environmental Science and Health, Part B 44, no. 7 (September 4, 2009): 657–62, doi:10.1080/03601230903163624.

37. Yolanda Lorenzo, Aamia Azqueta, Luisa Luna, Félix Bonilla, Gemma Dominguez, and Andrew R. Collins, “The Carotenoid β-Cryptoxanthin Stimulates the Repair of DNA Oxidation Damage in Addition to Acting as an Antioxidant in Human Cells,” Carcinogenesis 30, no. 2 (December 4, 2008): 308–14, doi:10.1093/carcin/bgn270.

38. Pesticide Action Network, “Sweet Bell Peppers,” What's on My Food? accessed November 3, 2016, http://whatsonmyfood.org/food.jsp?food=PP.

Глава 4. Сахар, рак и кетогенная диета

1. Lise Alschuler and Karolyn A. Gazella, The Definitive Guide to Cancer: An Integrative Approach to Prevention, Treatment, and Healing (New York: Celestial Arts, 2010).

2. Wanxing Duan, Xin Shen, Jianjun Lei, Quinhong Xu, Yongtian Yu, Rong Li, Erxi Wu, and Qingyong Ma, “Hyperglycemia, a Neglected Factor during Cancer Progression,” BioMed Research International 2014, no. 4176 (February 2014): 1–10, doi:10.1155/2014/461917.

3. Joseph E. Pizzorno and Michael T. Murray, Textbook of Natural Medicine (St. Louis, MO: Churchill Livingstone Elsevier, 2006).

4. Rachel K. Johnson, Lawrence J. Appel, Michael Brands, Barbara V. Howard, Michael Lefevre, Robert H. Lustig, Frank Sacks, et al., “Dietary Sugars Intake and Cardiovascular Health: A Scientific Statement from the American Heart Association,” Circulation 120, no. 11 (August 24, 2009): 1011–20, doi:10.1161/CIRCULATIONAHA.109.192627.

5. George A. Bray, Samara Joy Nielsen, and Barry M. Popkin, “Consumption of High-Fructose Corn Syrup in Beverages May Play a Role in the Epidemic of Obesity,” American Journal of Clinical Nutrition 79, no. 4 (April 2004): 537–43, http://ajcn.nutrition.org/content/79/4/537.abstract.

6. Zhong Q. Wang, Aamir R. Zuberi, Xian H. Zhang, Jacalyn Macgowan, Jianhua Qin, Xin Ye, Leslie Son, Qinglin Wu, Kun Lian, and William T. Cefalu, “Effects of Dietary Fibers on Weight Gain, Carbohydrate Metabolism, and Gastric Ghrelin Gene Expression in Mice Fed a High-Fat Diet,” Metabolism 56, no. 12 (December 2007): 1635–42, doi:10.1016/j.metabol.2007.07.004.

7. NIH, “Lactose Intolerance,” Genetics Home Reference, accessed November 20, 2016, https://ghr.nlm.nih.gov/condition/lactose-intolerance.

8. Susanna Larsson, Leif Bergkvist, and Alicja Wolk, “Milk and Lactose Intakes and Ovarian Cancer Risk in the Swedish Mammography Cohort,” American Journal of Clicnical Nutrition 80, no. 5 (November 2004): 1353–57, http://ajcn.nutrition.org/content/80/5/1353.full.

9. Andrew Curry, “Archaeology: The Milk Revolution,” Nature 500, no. 7460 (July 31, 2013): 20–22, doi:10.1038/500020a.

10. Kei Nakajima, Tohru Nemoto, Toshitaka Muneyuki, Masafumi Kakei, Hiroshi Fuchigami, and Hiromi Munakata, “Low Serum Amylase in Association with Metabolic Syndrome and Diabetes: A Community-Based Study,” Cardiovascular Diabetology 10 (April 17, 2011): 34, doi:10.1186/1475-2840-10-34.

11. Pinna Rolfes and Whitney Rolfes, Understanding Normal and Clinical Nutrition (Brooks Cole, 2011).

12. NIH, “Overweight and Obesity Statistics,” US Department of Health and Human Services, accessed January 12, 2017, https://www.niddk.nih.gov/ health-information/health-statistics/Documents/stat904z.pdf.

13. Edward Giovannucci, David M. Harlan, Michael C. Archer, Richard M. Bergenstal, Susan M. Gapstur, Laurel A. Habel, Michael Pollak, Judith G. Regensteiner, and Douglas Yee, “Diabetes and Cancer: A Consensus Report,” Diabetes Care 33, no. 7 (July 2010): 1674–85, doi:10.2337/dc10-0666.

14. Rainer J. Klement and Ulrike Kä mmerer, “Is There a Role for Carbohydrate Restriction in the Treatment and Prevention of Cancer?” Nutrition and Metabolism 8 (2011): 75, doi:10.1186/1743-7075-8-75.

15. Yasuhito Onodera, Jin-Min Nam, and Mina J. Bissell, “Increased Sugar Uptake Promotes Oncogenesis via EPAC/RAP1 and O-GlcNAc Pathways,” Journal of Clinical Investigation 124, no. 1 (January 2, 2014): 367–84, doi:10.1172/jci63146.

16. Yong Wu, Joy Lin, Landon G. Piluso, and Xuan Liu, “High Glucose Inhibits p53 Function via Thr55 Phosphorylation,” FASEB Journal 24, no. 1, supplement 503.5 (April 2010), http://www.fasebj.org/content/24/1_ Supplement/503.5.abstract.

17. S. A. Bustin and P. J. Jenkins, “The Growth Hormone-Insulin-Like Growth Factor-I Axis and Colorectal Cancer,” Trends in Molecular Medicine 7, no. 10 (October 2001): 447–54, doi:10.1016/S1471-4914(01)02104-9.

18. Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, et al., “Metabolic Reprogramming Induced by Ketone Bodies Diminishes Pancreatic Cancer Cachexia,” Cancer and Metabolism 2 (September 1, 2014): 18, doi:10.1186/2049-3002-2-18.

19. Neil McKinney, Naturopathic Oncology: An Encyclopedic Guide for Patients and Physicians (Richmond, BC: Creative Guy Publishing, 2010).

20. Ibid.

21. Wei-Xing Zong, Joshua D. Rabinowitz, and Eileen White, “Mitochondria and Cancer,” Molecular Cell 61, no. 5 (March 3, 2016): 667–76, doi:10.1016/j. molcel.2016.02.011.

22. Charles W. Schmidt, “Unraveling Environmental Effects on Mitochondria,” Environmental Health Perspectives 118, no. 7 (July 2010): A292–97, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2920932.

23. Susana Romero-Garcia, Marİa Maximina B. Moreno-Altamirano, Heriberto Prado-Garcia, and Francisco Javier Sánchez-Garcнa, “Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance,” Frontiers in Immunology 7 (February 16, 2016): 52, doi:10.3389/fimmu.2016.00052.

24. Thomas N. Seyfried, Roberto E. Flores, Angela M. Poff, and Dominic P. D'Agostino, “Cancer as a Metabolic Disease: Implications for Novel Therapeutics,” Carcinogenesis 35, no. 3 (December 2013): 515–27, doi:10.1093/ carcin/bgt480.

25. Bryan G. Allen, Sudershan K. Bhatia, Carryn M. Anderson, Julie M. Eichenberger-Gilmore, Zita A. Sibenaller, Kranti A. Mapuskar, Joshua D. Schoenfeld, John M. Buatti, Douglas R. Spitz, and Melissa A. Fath, “Ketogenic Diets as an Adjuvant Cancer Therapy: History and Potential Mechanism,” Redox Biology 2 (August 7, 2014): 963–70, doi:10.1016/j.redox.2014.08.002.

26. Stephen D. Hursting, Sarah M. Dunlap, Nikki A. Ford, Marcie J. Hursting, and Laura M. Lashinger, “Calorie Restriction and Cancer Prevention: A Mechanistic Perspective,” Cancer and Metabolism 1 (March 7, 2013): 10, doi:10.1186/2049-3002-1-10.

Глава 5. Канцерогены, рак и детоксикация

1. Anne Platt McGinn, “POPs Culture,” World Watch Magazine 13, no. 2 (March/April 2000), http://www.worldwatch.org/node/485.

2. Xiaomei Ma, Patricia A. Buffler, Robert B. Gunier, Gary Dahl, Martyn T. Smith, Kyndaron Reinier, and Peggy Reynolds, “Critical Windows of Exposure to Household Pesticides and Risk of Childhood Leukemia,” Environmental Health Perspectives 110, no. 9 (September 2002): 955–60, https://www.ncbi. nlm.nih.gov/pmc/articles/PMC1240997.

3. Michael T. Murray and Joseph E. Pizzorno, Encyclopedia of Natural Medicine (Rocklin, CA: Prima Publishing, 1998).

4. Ellen K. Silbergeld, Daniele Mandrioli, and Carl F. Cranor, “Regulating Chemicals: Law, Science, and the Unbearable Burdens of Regulation,” Annual Review of Public Health 36 (March 2015): 175–195, doi:10.1146/annurev-publhealth-031914-122654.

5. M. T. Smith, K. Z. Guyton, C. F. Gibbons, J. M. Fritz, C. J. Portier, I. Rusyn, D. M. DeMarini, et al., “Key Characteristics of Carcinogens as a Basis for Organizing Data on Mechanisms of Carcinogens,” Environmental Health Perspectives 124, no. 6 (June 2016): 713–21, doi:10.1289/ehp.1509912.

6. Sharon Ruth Skolnick, “Exposing Airports' Poison Circles,” Earth Island Journal 15, no. 4 (Winter 2000–2001), http://www.areco.org/ExpAir.pdf.

7. Maria E. Morales, Revecca S. Derbes, Catherine M. Ade, Jonathan C. Ortego, Jeremy Stark, Prescott L. Deininger, and Astrid M. Roy-Engel, “Heavy Metal Exposure Influences Double Strand Break DNA Repair Outcomes,” PLOS ONE 11, no. 3 (March 11, 2016): e0151367, doi:10.1371/journal.pone.0151367.

8. “Casings,” FAO Corporate Document Repository, accessed November 21, 2016, http://www.fao.org/docrep/010/ai407e/AI407E20.htm.

9. Gary D. Friedman, Natalia Udaltsova, James Chan, Charles P. Quesenberry, and Laurel A. Habel, “Screening Pharmaceuticals for Possible Carcinogenic Effects: Initial Positive Results for Drugs Not Previously Screened,” Cancer Causes and Control 20, no. 10 (December 2009): 1821–35, doi:10.1007/s10552-009-9375-2.

10. John Neustadt and Steve R. Pieczenik, “Medication-Induced Mitochondrial Damage and Disease,” Molecular Nutrition and Food Research 52, no. 7 (July 2008): 780–88, doi:10.1002 /mnfr.200700075.

11. Henry Delincée and Beatrice-Louise Pool-Zobel, “Genotoxic Properties of 2-Dodecylcyclobutanone, a Compound Formed on Irradiation of Food Containing Fat,” Radiation Physics and Chemistry 52, no. 1 (June 1998): 39–42, doi:10.1016/S0969-806X(98)00070-X.

12. Mathieu Boniol, Philippe Autier, Peter Boyle, and Sara Gandini, “Cutaneous Melanoma Attributable to Sunbed Use: Systematic Review and Meta-Analysis,” BMJ 345 (July 24, 2012): e4757, doi:10.1136/bmj.e4757.

13. William E. Sumner, Leonidas G. Koniaris, Sarah E. Snell, Seth Spector, Jodeen Powell, Eli Avisar, Frederick Moffat, Alan S. Livingstone, and Dido Franceschi, “Results of 23,81 °Cases of Ductal Carcinoma-in-Situ,” Annals of Surgical Oncology 14, no. 5 (May 2007): 1638–43, doi:10.1245/s10434-006-9316-1.

14. Joseph E. Pizzorno, and Michael T. Murray, Textbook of Natural Medicine (St. Louis, MO: Churchill Livingstone Elsevier, 2006).

15. John C. Cline, “Nutritional Aspects of Detoxification in Clinical Practice,” Alternative Therapies in Health and Medicine, May/June 2015, https://issuu.com/presspad/docs/i14004.

16. Katrina Blair, The Wild Wisdom of Weeds: 13 Essential Plants for Human Survival (White River Junction, VT: Chelsea Green Publishing, 2014).

17. Vasil Georgiev Georgiev, Jost Weber, Eva-Maria Kneschke, Petko Nedyalkov Denev, Thomas Bley, and Atanas Ivanov Pavlov, “Antioxidant Activity and Phenolic Content of Betalain Extracts from Intact Plants and Hairy Root Cultures of the Red Beetroot Beta vulgaris cv. Detroit Dark Red,” Plant Foods for Human Nutrition 65, no. 2 (June 2010): 105–11, doi:10.1007/ s11130-010-0156-6.

18. M. N. Gould, “Cancer Chemoprevention and Therapy by Monoterpenes,” Environmental Health Perspectives 105, supplement 4 (June 1997): 977–79, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1470060.

19. Emey Suhana Mohd Azamai, Suhaniza Sulaiman, Shafina Hanim Mohd Habib, Mee Lee Looi, Srijit Das, Nor Aini Abdul Hamid, Wan Zurinah Wan Ngah, and Yasmin Anum Mohd Yusof, “Chlorella vulgaris Triggers Apoptosis in Hepatocarcinogenesis-Induced Rats,” Journal of Zhejiang University Science B, 10, no. 1 (January 2009): 14–21, doi:10.1631/jzus.B0820168.

20. Patricia A. Egner, Jin-Bing Wang, Yuan-Rong Zhu, Bau-Chu Zhang, Yan Wu, Qi-Nan Zhang, Geng-Sun Qian, et al., “Chlorophyllin Intervention Reduces Aflatoxin-DNA Adducts in Individuals at High Risk for Liver Cancer,” Proceedings of the National Academy of Science of the United States of America 98, no. 25 (December 4, 2001): 14601–6, doi:10.1073/pnas.251536898.

21. Stefania Miccadei, Donato Di Venere, Angela Cardinali, Ferdinando Romano, Alessandra Durazzo, Maria Stella Foddai, Rocco Fraioli, Sohrab Mobarhan, and Giuseppe Maiani, “Antioxidative and Apoptotic Properties of Polyphenolic Extracts from Edible Part of Artichoke (Cynara scolymus L.) on Cultured Rat Hepatocytes and on Human Hepatoma Cells,” Nutrition and Cancer 60, no. 2 (March 2008): 276–83, doi:10.1080/01635580801891583.

22. Lizzia Raffaghello, Changhan Lee, Fernando M. Safdie, Min Wei, Federica Madia, Giovanna Bianchi, and Valter D. Longo, “Starvation-Dependent Differential Stress Resistance Protects Normal but Not Cancer Cells against High-Dose Chemotherapy,” Proceedings of the National Academy of Sciences of the United States of America 105, no. 24(June 17, 2008): 8215–20, doi:10.1073/ pnas.0708100105.

23. Stephen D. Hursting, Jackie A. Lavigne, David Berrigan, Susan N. Perkins, and J. Carl Barrett, “Calorie Restriction, Aging, and Cancer Prevention: Mechanisms of Action and Applicability to Humans,” Annual Review of Medicine 54 (February 2003): 131–52, doi:10.1146/annurev. med.54.101601.152156.

Глава 6. Могущественный микробиом

1. Scott J. Bultman, “Emerging Roles of the Microbiome in Cancer,” Carcinogenesis 35, no. 2 (February 2014): 249–55, doi:10.1093/carcin/bgt392.

2. Fredrik Bäckhed, Ruth E. Ley, Justin L. Sonnenburg, Daniel A. Peterson, and Jeffery I. Gordon, “Host-Bacterial Mutualism in the Human Intestine,” Science 307, no. 5717 (March 25, 2005): 1915–20, doi:10.1126/science.1104816.

3. Ian F. N. Hung and Benjamin C. Y. Wong, “Assessing the Risks and Benefits of Treating Helicobacter pylori Infection,” Therapeutic Advances in Gastroenterology 2, no. 3 (May 2009): 141–47, doi:10.1177/1756283x08100279.

4. Tina J. Hieken, Jun Chen, Tanya L. Hoskin, Marina Walther-Antonio, Stephen Johnson, Sheri Ramaker, Jian Xiao, et al., “The Microbiome of Aseptically Collected Human Breast Tissue in Benign and Malignant Disease,” Scientific Reports 6 (August 3, 2016): 30751, doi:10.1038/srep30751.

5. Josef Neu and Jona Rushing, “Cesarean Versus Vaginal Delivery: LongTerm Infant Outcomes and the Hygiene Hypothesis,” Clinics in Perinatology 38, no. 2 (June 2011): 321–31, doi:10.1016/j.clp.2011.03.008.

6. Bidisha Paul, Stephen Barnes, Wendy Demark-Wahnefried, Casey Morrow, Carolina Salvador, Christine Skibola, and Trygve O. Tollefsbol, “Influences of Diet and the Gut Microbiome on Epigenetic Modulation in Cancer and Other Diseases,” Clinical Epigenetics 7, no. 1 (October 16, 2015): 112, doi:10.1186/s13148-015-0144-7.

7. Laura B. Bindels and Jean-Paul Thissen, “Nutrition in Cancer Patients with Cachexia: A Role for the Gut Microbiota?” Clinical Nutrition Experimental 6 (April 2016): 74–82, doi:10.1016/j.yclnex.2015.11.001.

8. “Microbes in the Human Body,” The Marshall Protocol Knowledge Base, accessed August 21, 2016, http://mpkb.org/home/pathogenesis/microbiota.

9. Maureen P. Corry, “The Cost of Having a Baby in the United States,” Childbirth Connections, May 9, 2013, http://www.medscape.com/ viewarticle/803426_2.

10. Meredith Betz, “C-Section Trends Out of Control in South Florida,” Nonprofit Quarterly, October 12, 2015, https://nonprofitquarterly. org/2015/10/12/c-section-trends-out-of-control-in-south-florida.

11. Neu and Rushing, “Cesarean Versus Vaginal Delivery: Long-Term Infant Outcomes and the Hygiene Hypothesis.”

12. Alison Stuebe, “The Risks of Not Breastfeeding for Mothers and Infants,” Reviews in Obstetrics and Gynecology 2, no. 4 (Fall 2009): 222–31, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2812877.

13. Antonio M. Persico and Valerio Napolioni, “Urinary P-Cresol in Autism Spectrum Disorder,” Neurotoxicology and Teratology 36 (March 2013): 82–90, doi:10.1016/j.ntt.2012.09.002.

14. Gordon E. Schutze, Rodney E. Willoughby, Michael T. Brady, Carrie L. Byington, H. Dele Davies, Kathryn M. Edwards, Mary P. Glode, et al., “Clostridium Difficile Infection in Infants and Children,” Pediatrics 131, no. 1 (January 1, 2013): 196–200, doi:10.1542/peds.2012–2992.

15. Anthony Samsel and Stephanie Seneff, “Glyphosate, Pathways to Modern Diseases II: Celiac Sprue and Gluten Intolerance,” Interdisciplinary Toxicology 6, no. 4 (December 2013): 159–84, doi:10.2478/intox-2013-0026.

16. Benoit Chassaing, Omry Koren, Julia K. Goodrich, Angela C. Poole, Shanthi Srinivasan, Ruth E. Ley, and Andrew T. Gewirtz, “Dietary Emulsifiers Impact the Mouse Gut Microbiota Promoting Colitis and Metabolic Syndrome,” Nature 519, no. 7541 (March 5, 2015): 92–96, doi:10.1038/nature14232.

17. Sameer Kalghatgi, Catherine S. Spina, James C. Costello, Marc Liesa, J. Ruben Morones-Ramirez, Shimyn Slomovic, Anthony Molina, Orian S. Shirihai, and James J. Collins, “Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian Cells,” Science Translational Medicine 5, no. 192 (July 3, 2013): 192ra85, doi:10.1126/scitranslmed.3006055.

18. Jo Robinson, Eating on the Wild Side: The Missing Link to Optimum Health (New York: Little, Brown and Company, 2013).

19. Surajit Karmakar, Subhasree Roy Choudhury, Naren L. Banik, and Swapan K. Ray, “Molecular Mechanisms of Anti-Cancer Action of Garlic Compounds in Neuroblastoma,” Anti-Cancer Agents in Medicinal Chemistry 11, no. 4 (May 2011): 398–407, doi:10.2174/187152011795677553.

20. Bharat B. Aggarwal and Debora Yost, Healing Spices: How to Use 50 Everyday and Exotic Spices to Boost Health and Beat Disease (New York: Sterling Publishing, 2011).

21. Georgetown University Medical Center, “Oregano Oil May Protect Against Drug-Resistant Bacteria, Georgetown Researcher Finds,” ScienceDaily, October 11, 2001, https://www.sciencedaily.com/ releases/2001/10/011011065609.htm.

22. Sue C. Chao, D. Gary Young, and Craig J. Oberg, “Effect of a Diffused Essential Oil Blend on Bacterial Bioaerosols,” Journal of Essential Oil Research 10, no. 5 (September 1998): 517–23, doi:10.1080/10412905.1998.9700958.

23. Zhanguo Gao, Jun Yin, Jin Zhang, Robert E. Ward, Roy J. Martin, Michael Lefevre, William T. Cefalu, and Jianping Ye, “Butyrate Improves Insulin Sensitivity and Increases Energy Expenditure in Mice,” Diabetes 58, no. 7 (July 2009): 1509–17, doi:10.2337/db08-1637.

24. Sunisa Siripongvutikorn, Ruttiya Asksonthong, and Worapong Usawakesmanee, “Evaluation of Harmful Heavy Metal (Hg, Pb and Cd) Reduction Using Halomonas elongata and Tetragenococcus halophilus for Protein Hydrolysate Product,” Functional Foods in Health and Disease 6, no. 4 (April 27, 2016): 195–205, http://ffhdj.com/index.php/ffhd/article/view/240.

25. J. Beuth, H. L. Ko, K. Oette, G. Pulverer, K. Roszkowski, and G. Uhlenbruck, “Inhibition of Liver Metastasis in Mice by Blocking Hepatocyte Lectins with Arabinogalactan Infusions and D-Galactose,” Journal of Cancer Research and Clinical Oncology 113, no. 1 (February 1987): 51–55, doi:10.1007/ BF00389966.

26. Hyunnho Cho, Hana Jung, Heejae Lee, Hae Chang Yi, Ho-kyung Kwak, and Keum Taek Hwang, “Chemopreventive Activity of Ellagitannins and Their Derivatives from Black Raspberry Seeds on HT-29 Colon Cancer Cells,” Food and Function 6, no. 5 (May 2015): 1675–83, doi:10.1039/c5fo00274e.

Глава 7. Иммунная система

1. Adit A. Ginde, Mark C. Liu, and Carlos A. Camargo, “Demographic Differences and Trends of Vitamin D Insufficiency in the US Population, 1988–2004,” Archives of Internal Medicine 169, no. 6 (March 23, 2009): 626–32, doi:10.1001/archinternmed.2008.604.

2. Marina Rode von Essen, Martin Kongsbak, Peter Scherling, Klaus Olgaard, Niels Шdum, and Carsten Geisler, “Vitamin D Controls T Cell Antigen Receptor Signaling and Activation of Human T Cells,” Nature Immunology 11 (2010): 334–49, doi:10.1038/ni.1851.

3. A. Katharina Simon, Georg A. Hollander, and Andrew McMichael, “Evolution of the Immune System in Humans from Infancy to Old Age,” Proceedings of the Royal Society B: Biological Sciences 282, no. 1821 (December 22, 2015): 20143085, doi:10.1098/rspb.2014.3085.

4. Keith Block. Life over Cancer: The Block Center Program for Integrative Cancer Treatment (New York: Bantam Dell, 2009).

5. Dicken Weatherby and Scott Ferguson, Blood Chemistry and CBC Analysis: Clinical Laboratory Testing from a Functional Perspective (Jacksonville, OR: Bear Mountain Publishing, 2002).

6. Alessio Fasano, “Zonulin, Regulation of Tight Junctions, and Autoimmune Diseases,” Annals of the New York Academy of Sciences 1258, no. 1 (July 2012): 25–33, doi:10.1111/j.1749–6632.2012.06538.x.

7. Marco Skardelly, Franz Paul Armbruster, Jьrgen Meixensberger, Heidegard Hilbig, “Expression of Zonulin, C-Kit, Glial Fibrillary Acidic Protein in Human Gliomas,” Translational Oncology 2, no. 3 (September 2009): 117–20, doi:10.1593/tlo.09115.

8. A. Fasano, “Zonulin and Its Regulation of Intestinal Barrier Function: The Biological Door to Inflammation, Autoimmunity, and Cancer,” Physiological Reviews 91, no. 1 (January 2011): 151–75, doi:10.1152/physrev.00003.2008.

9. Aristo Vojdani, “Lectins, Agglutinins, and Their Roles in Autoimmune Reactivities,” Alternative Therapies in Health and Medicine 21, supplement 1 (2015): 46–51, https://www.ncbi.nlm.nih.gov/pubmed/25599185.

10. Margit Brottveit, Ann-Christin R. Beitnes, Stig Tollefsen, Jorunn E. Bratlie, Frode L. Jahnsen, Finn-Eirik Johansen, Ludvig M. Sollid, and Knut E. A. Lundin, “Mucosal Cytokine Response after Short-Term Gluten Challenge in Celiac Disease and Non-Celiac Gluten Sensitivity,” American Journal of Gastroenterology 108, no. 5 (May 2013): 842–50, doi:10.1038/ajg.2013.91.

11. R. K. Chandra, “Nutrition and the Immune System: An Introduction,” American Journal of Clinical Nutrition 66, no. 2 (August 1997): 460s–63, https://www.ncbi.nlm.nih.gov/pubmed/9250133.

12. Joseph E. Pizzorno and Michael T. Murray, Textbook of Natural Medicine (St. Louis, MO: Churchill Livingstone Elsevier, 2006).

13. Andrew L. Kau, Philip P. Ahern, Nicholas W. Griffin, Andrew L. Goodman, and Jeffrey I. Gordon, “Human Nutrition, the Gut Microbiome, and Immune System,” Nature 474, no. 7351 (June 15, 2011): 327–36, doi:10.1038/ nature10213.

14. John M. Daly, John Reynolds, Robert K. Sigal, Jian Shou, and Michael D. Liberman, “Effect of Dietary Protein and Amino Acids on Immune Function,” Critical Care Medicine 18, supplement 2 (February 1990): s86–93, https://www. ncbi.nlm.nih.gov/pubmed/2105184.

15. Peng Li, Yu-Long Yin, Defa Li, Sung Woo Kim, and Guoyao Wu, “Amino Acids and Immune Function,” British Journal of Nutrition 98, no. 2 (August 2007): 237–52, doi:10.1017/S000711450769936X.

16. R. K. Chandra, “Protein-Energy Malnutrition and Immunological Responses,” Journal of Nutrition 122, supplement 3 (March 1992): 597–600, https://www.ncbi.nlm.nih.gov/pubmed/1542017.

17. Pizzorno and Murray, Textbook of Natural Medicine.

18. K. Pino-Lagos, M. J. Benson, and R. J. Noelle, “Retinoic Acid in the Immune System,” Annals of the New York Academy of Sciences 1143 (November 2008): 170–87, doi:10.1196/annals.1443.017.

19. Katherine Zerdin, Michael L. Rooney, and Joost Vermuë, “The Vitamin C Content of Orange Juice Packed in an Oxygen Scavenger Material,” Food Chemistry 82, no. 3 (August 2003): 387–95, doi:10.1016/s0308-8146(02)00559-9.

20. Hafeez Ullah Janjua, Munir Akhtar, and Fayyaz Hussain, “Effects of Sugar, Salt and Distilled Water on White Blood Cells and Platelet Cells,” Journal of Tumor 4, no. 1 (February 2, 2016): 354–58, http://www.ghrnet.org/index. php/JT/article/view/1340.

21. Michael T. Murray, Encyclopedia of Nutritional Supplements: The Essential Guide for Improving Your Health Naturally (Rocklin, CA: Prima Health, 1996).

22. E. S. Wintergerst, S. Maggini, and D. H. Hornig, “Contribution of Selected Vitamins and Trace Elements to Immune Function,” Annals of Nutrition and Metabolism 51, no. 4 (September 2007): 301–23, doi:10.1159/000107673.

23. Cynthia Aranow. “Vitamin D and the Immune System,” Journal of Investigative Medicine 59, no. 6 (August 2011): 881–86, doi:10.231/ JIM.0b013e31821b8755.

24. Johan Moan, Zoya Lagunova, Øyvind Bruland, and Asta Juzeniene, “Seasonal Variations of Cancer Incidence and Prognosis,” DermatoEndocrinology 2, no. 2 (April 2010): 55–57, doi:10.4161/derm.2.2.12664.

25. Lisa A. Houghton and Reinhold Vieth, “The Case against Ergocalciferol (Vitamin D2) as a Vitamin Supplement,” American Journal of Clinical Nutrition 84, no. 4 (October 2006): 694–97, http://ajcn.nutrition.org/content/84/4/694. long.

26. Ruth Sánchez-Martínez, Alberto Zambrano, Ana I. Castillo, and Ana Aranda, “Vitamin D – Dependent Recruitment of Corepressors to Vitamin D / Retinoid X Receptor Heterodimers,” Molecular and Cellular Biology, 28, no. 11 (March 24, 2008): 3817–29, doi:10.1128/MCB.01909-07.

27. Cedric F. Garland, Frank C. Garland, Edward D. Gorham, Marin Lipkin, Harold Newmark, Sharif B. Mohr, and Michael F. Holick, “The Role of Vitamin D in Cancer Prevention,” American Journal of Public Health 96, no. 2 (February 2006): 252–61, doi:10.2105/AJPH.2004.045260.

28. Elzbieta Kowalska, Steven A. Narod, Tomasz Huzarski, Stanislaw Zajaczek, Jowita Huzarska, Bohdan Gorski, and Jan Lubinski, “Increased Rates of Chromosome Breakage in BRCA1 Carriers Are Normalized by Oral Selenium Supplementation,” Cancer Epidemiology, Biomarkers and Prevention 14, no. 5 (May 13, 2005): 1302–6, doi:10.1158/1055-9965.EPI-03-0448.

29. A. H. Shankar and A. S. Prasad, “Zinc and Immune Function: The Biological Basis of Altered Resistance to Infection,” American Journal of Clinical Nutrition 68, supplement 2 (August 1998): 447s–63, https://www.ncbi.nlm.nih. gov/pubmed/9701160.

30. Janet R. K. Hunt. “Bioavailability of Iron, Zinc, and Other Trace Minerals from Vegetarian Diets,” American Journal of Clinical Nutrition 78, no. 3 (September 2003): 633–639, http://ajcn.nutrition.org/content/78/3/633S. full.

31. Mitchell R. McGill, Matthew R. Sharpe, C. David Williams, Mohammad Taha, Steven C. Curry, and Hartmut Jaeschke, “The Mechanism Underlying Acetaminophen-Induced Hepatotoxicity in Humans and Mice Involves Mitochondrial Damage and Nuclear DNA Fragmentation,” Journal of Clinical Investigation 122, no. 4 (April 2, 2012): 1574–83, doi:10.1172/JCI59755.

32. Seema Patel and Arun Goyal, “Recent Developments in Mushrooms as Anti-Cancer Therapeutics: A Review,” 3 Biotech 2, no. 1 (March 2012): 1–15, doi:10.1007/s13205-011-0036-2.

33. Carolyn J. Torkelson, Erine Sweet, Mark R. Martzen, Masa Sasagawa, Cynthia A. Wenner, Juliette Gay, Amy Putiri, and Leanna J. Standish, “Phase 1 Clinical Trial of Trametes versicolor in Women with Breast Cancer,” ISRN Oncology 2012 (May 30, 2012): 251632, doi:10.5402/2012/251632.

34. Alena G. Guggenheim, Kirsten M. Wright, and Heather L. Zwickey, “Immune Modulation from Five Major Mushrooms: Application to Integrative Oncology,” Integrative Medicine 13, no. 1 (February 2014): 32–44, https://www. ncbi.nlm.nih.gov/pmc/articles/PMC4684115.

35. Xiaoshuang Dai, Joy M. Stanilka, Cheryl A. Rowe, Elizabethe A. Esteves, Carmelo Nieves, Samuel J. Spaiser, Mary C. Christman, Bobbi Langkamp-Henken, and Susan S. Percival, “Consuming Lentinula edodes (Shiitake) Mushrooms Daily Improves Human Immunity: A Randomized Dietary Intervention in Healthy Young Adults,” Journal of the American College of Nutrition 34, no. 6 (2015): 478–87, doi:10.1080/07315724.2014.950391.

36. Sissi Wachtel-Galor, John Yuen, John A. Buswell, and Iris F. F. Benzie, “Ganoderma lucidum (Lingzhi or Reishi): A Medicinal Mushroom,” chap. 9 in Iris F. F. Benzie and Sissi Wachtel-Galor, eds., Herbal Medicine: Biomolecular and Clinical Aspects, 2nd ed. (Boca Raton, FL: CRC Press, 2011). Available from https://www.ncbi.nlm.nih.gov/books/NBK92757.

37. Patel and Goyal, “Recent Developments in Mushrooms as Anti-Cancer Therapeutics: A Review.”

38. Bao-qin Lin and Shao-ping Li, “Cordyceps as an Herbal Drug,” chap. 5 in Benzie and Wachtel-Galor, eds., Herbal Medicine: Biomolecular and Clinical Aspects. Available at https://www.ncbi.nlm.nih.gov/books/NBK92758.

39. Qing Li, “Effect of Forest Bathing Trips on Human Immune Function,” Environmental Health and Preventive Medicine 15, no. 1 (January 2010): 9–17, doi:10.1007/s12199-008-0068-3.

40. A. Mooventhan and L. Nivethitha, “Scientific Evidence-Based Effects of Hydrotherapy on Various Systems of the Body,” North American Journal of Medical Sciences 6, no. 5 (May 2014): 199–209, doi:10.4103/1947-2714.132935.

Глава 8. Взаимосвязь воспаления и окисления

1. Subrata Kumar Biswas, “Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?” Oxidative Medicine and Cellular Longevity 2016, no. 12 (January 2016): 1–9, doi:10.1155/2016/5698931.

2. Udo Erasmus, Fats That Heal, Fats That Kill: The Complete Guide to Fats, Oils, Cholesterol and Human Health (Burnaby, BC: Alive Books, 1996).

3. Daniel Weber, Inflammation and the Seven Stochastic Events of Cancer (Alexandria, NSW: Panaxea Publishing, 2010).

4. Mary M. Murphy, Leila M. Barraj, Dena Herman, Xiaoyu Bi, Rachel Cheatham, and R. Keith Randolph, “Phytonutrient Intake by Adults in the United States in Relation to Fruit and Vegetable Consumption,” Journal of the Academy of Nutrition and Dietetics 112, no. 2 (February 2012): 222–29, doi:10.1016/j.jada.2011.08.044.

5. “Omega-6 Polyunsaturated Fatty Acids and DNA Adducts,” Food and Chemical Toxicology 35, no. 10–11 (October/November 1997): 1131, doi:10.1016/s0278-6915(97)90098-3.

6. Jian-Hua Yi, Dong Wang, Zhi-Yong Li, Jun Hu, Xiao-Feng Niu, and Xiao-Lin Liu, “C-Reactive Protein as a Prognostic Factor for Human Osteosarcoma: A Meta-Analysis and Literature Review,” PLOS ONE 9, no. 5 (May 6, 2014): doi:10.1371/journal.pone.0094632.

7. Jill K. Onesti and Denis C. Guttridge, “Inflammation Based Regulation of Cancer Cachexia,” BioMed Research International 2014 (May 4, 2014): 1–7, doi:10.1155/2014/168407.

8. Norleena P. Gullett, Vera C. Mazurak, Gautam Hebbar, and Thomas R. Ziegler, “Nutritional Interventions for Cancer-Induced Cachexia,” Current Problems in Cancer 35, no. 2 (March/April 2011): 58–90, doi:10.1016/j. currproblcancer.2011.01.001.

9. Surendra K. Shukla, Teklab Gebregiworgis, Vinee Purohit, Nina V. Chaika, Venugopal Gunda, Prakash Radhakrishnan, Kamiya Mehla, et al., “Metabolic Reprogramming Induced by Ketone Bodies Diminishes Pancreatic Cancer Cachexia,” Cancer and Metabolism 2, no. 1 (September 1, 2014): 18, doi:10.1186/2049-3002-2-18.

10. David F. Horrobin, “Loss of Delta-6-Sesaturase Activity as a Key Factor in Aging,” Medical Hypotheses 7, no. 9 (1981): 1211–20, doi:10.1016/0306-9877(81)90064-5; Federica Tosi, Filippo Sartori, Patrizia Guarini, Oliviero Olivieri, and Nicola Martinelli, “Delta-5 and Delta-6 Desaturases: Crucial Enzymes in Polyunsaturated Fatty Acid-Related Pathways with Pleiotropic Influences in Health and Disease,” Advances in Experimental Medicine and Biology 824 (2014): 61–81, doi:10.1007/978-3-319-07320-0_7.

11. R. A. Kunin, “Snake Oil,” Western Journal of Medicine 151, no. 2 (August 1989): 208, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1026931.

12. Paulette Mehta, “TNF-α Inhibitors: Are They Carcinogenic?” Drug, Healthcare and Patient Safety 2 (2010): 241–47, doi:10.2147/dhps.s7829.

13. Tzung-Jiun Tsai and Ping-I Hsu, “Low-Dose Aspirin-Induced Upper Gastrointestinal Injury – Epidemiology, Management and Prevention,” Journal of Blood Disorders and Transfusion 6 (December 26, 2015): 327, doi:10.4172/2155-9864.1000327.

14. Daniel Arango, Kengo Morohashi, Alper Yilmaz, Kouji Kuramochi, Arti Parihar, Bledj Brahimaj, Erich Grotewold, and Andrea I. Doseff, “Molecular Basis for the Action of a Dietary Flavonoid Revealed by the Comprehensive Identification of Apigenin Human Targets,” Proceedings of the National Academy of Sciences 110, no. 24 (May 2013): e2153–62, doi:10.1073/ pnas.1303726110.

15. Saebyeol Jang, Keith W. Kelley, and Rodney W. Johnson, “Luteolin Reduces IL-6 Production in Microglia by Inhibiting JNK Phosphorylation and Activation of AP-1,” Proceedings of the National Academy of Sciences 105, no. 21 (March 5, 2008): 7534–39, doi:10.1073/pnas.0802865105.

16. Michelle L. Boland, Aparajita H. Chourasia, and Kay F. Macleod, “Mitochondrial Dysfunction in Cancer,” Frontiers in Oncology 3 (December 2, 2013): 292, doi:10.3389/fonc.2013.00292.

17. Guoyao Wu, Yun-Zhong Fang, Sheng Yang, Joanne R. Lupton, and Nancy D. Turner, “Glutathione Metabolism and Its Implications for Health,” Journal of Nutrition 134, no. 3 (March 2004): 489–92, https://www.ncbi.nlm.nih.gov/pubmed/14988435.

18. Hu Wang, Tin Khor, Limin Shu, Zheng-Yuan Su, Francisco F. Fuentes, Jong Hun Lee, and Ah-Ng Tony Kong, “Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability,” Anti-Cancer Agents in Medicinal Chemistry 12, no. 10 (May 2012): 1281–305, doi:10.2174/187152012803833026.

19. Massimo Fantini, Monica Benvenuto, Laura Masuelli, Giovanni Vanni Frajese, Ilaria Tresoldi, Andrea Modesti, and Roberto Bei, “In Vitro and in Vivo Antitumoral Effects of Combinations of Polyphenols, or Polyphenols and Anticancer Drugs: Perspectives on Cancer Treatment,” International Journal of Molecular Sciences 16, no. 5 (May 2015): 9236–82, doi:10.3390/ijms16059236.

20. Ching-Chow Chen, Man-Ping Chow, Wei-Chien Huang, Yi-Chu Lin, and Ya-Jen Chang, “Flavonoids Inhibit Tumor Necrosis Factor-α-Induced Up-Regulation of Intercellular Adhesion Molecule-1 (ICAM-1) in Respiratory Epithelial Cells through Activator Protein-1 and Nuclear Factor-κB: StructureActivity Relationships,” Molecular Pharmacology 66, no. 3 (October 2004): 683–93, https://www.ncbi.nlm.nih.gov/pubmed/15322261.

21. Xiangsheng Xiao, Dingbo Shi, Liqun Liu, Jingshu Wang, Xiaoming Xie, Tiebang Kang, and Wuguo Deng, “Quercetin Suppresses Cyclooxygenase-2 Expression and Angiogenesis through Inactivation of P300 Signaling,” PLOS ONE 6, no. 8 (August 8, 2011): e22934, doi:10.1371/journal.pone.0022934; Iris Erlund, Jukka Marniemi, Paula Hakala, G. Alfthan, E. Meririnne, and A. Aro, “Consumption of Black Currants, Lingonberries and Bilberries Increases Serum Quercetin Concentrations,” European Journal of Clinical Nutrition 57, no. 1 (February 2003): 37–42, doi:10.1038/sj.ejcn.1601513.

22. J. Vlachojannis, F. Magora, and S. Chrubasik, “Willow Species and Aspirin: Different Mechanism of Actions,” Phytotherapy Research 25, no. 7 (2011): 1102–04, doi:10.1002/ptr.3386.

23. Reason Wilken, Mysore S. Veena, Marilene B. Wang, and Eri S. Srivatsan, “Curcumin: A Review of Anti-Cancer Properties and Therapeutic Activity in Head and Neck Squamous Cell Carcinoma,” Molecular Cancer 10, no. 1 (February 2011): 12, doi:10.1186/1476-4598-10-12.

24. Mark Barton Frank, Qing Yang, Jeanette Osban, Joseph T. Azzarello, Marcia R. Saban, Ricardo Saban, Richard A. Ashley, et al., “Frankincense Oil Derived from Boswellia carteri Induces Tumor Cell Specific Cytotoxicity,” BMC Complementary and Alternative Medicine 9 (March 18, 2009): 6, doi:10.1186/1472-6882-9-6.

25. S. D. Bhale, Z. Xu, W. Prinyawiwatkul, Joan M. King, and J. S. Godber, “Oregano and Rosemary Extracts Inhibit Oxidation of Long-Chain N-3 Fatty Acids in Menhaden Oil,” Journal of Food Science 72, no. 9 (December 2007): C504–8, doi:10.1111/j.1750–3841.2007.00569.x.

26. John Kallas, Edible Wild Plants: Wild Foods from Dirt to Plate (Layton, UT: Gibbs Smith, 2010).

27. I. AndÚjar, M. C. Recio, R. M. Giner, and J. L. Rİos, “Cocoa Polyphenols and Their Potential Benefits for Human Health,” Oxidative Medicine and Cellular Longevity 2012 (October 24, 2012): 1–23, doi:10.1155/2012/906252.

28. Andrea Rosanoff, Connie M. Weaver, and Robert K. Rude, “Suboptimal Magnesium Status in the United States: Are the Health Consequences Underestimated?” Nutrition Reviews 70, no. 3 (March 2012): 153–64, doi:10.1111/j.1753–4887.2011.00465.x.

29. Robert Whang, “Magnesium Deficiency: Pathogenesis, Prevalence, and Clinical Implications,” American Journal of Medicine 82, no. 3A (April 1987): 24–29, doi:10.1016/0002-9343(87)90129-x.

30. James L. Oschman, Gaétan Chevalier, and Richard Brown, “The Effects of Grounding (Earthing) on Inflammation, the Immune Response, Wound Healing, and Prevention and Treatment of Chronic Inflammatory and Autoimmune Diseases,” Journal of Inflammation Research 8 (March 4, 2015): 83–96, doi:10.2147/jir.s69656.

Глава 9. Рост и распространение рака

1. Christopher I. Li, Janet R. Daling, Mei-Tzu Tang, Kara L. Haugen, Peggy L. Porter, and Kathleen E. Malone, “Use of Antihypertensive Medications and Breast Cancer Risk among Women Aged 55 to 74 Years,” JAMA Internal Medicine 173, no. 17 (September 23, 2013): 1629–37, https://www.ncbi.nlm. nih.gov/pubmed/23921840.

2. Peter Carmeliet, “Angiogenesis in Health and Disease,” Nature Medicine 9, no. 6 (June 2003): 653–60, doi:10.1038/nm0603-653.

3. Robert R. Langley and Isaiah J. Fidler, “The Seed and Soil Hypothesis Revisited – The Role of Tumor-Stroma Interactions in Metastasis to Different Organs,” International Journal of Cancer 128, no. 11 (June 1, 2011): 2527–35, doi:10.1002/ijc.26031.

4. Shalom Madar, Ido Goldstein, and Varda Rotter, “‘Cancer Associated Fibroblasts'– More than Meets the Eye,” Trends in Molecular Medicine 19, no. 8 (August 2013): 447–53, doi:10.1016/j.molmed.2013.05.004.

5. Raghu Kalluri and Michael Zeisberg, “Fibroblasts in Cancer,” Nature Reviews Cancer 6, no. 5 (May 2006): 392–401, doi:10.1038/nrc1877.

6. Neta Erez, Morgan Truitt, Peter Olson, S. T. Arron, and Douglas Hanahan, “Cancer-Associated Fibroblasts Are Activated in Incipient Neoplasia to Orchestrate Tumor-Promoting Inflammation in an NF-κB-Dependent Manner,” Cancer Cell 17, no. 2 (February 17, 2010): 135–47, doi:10.1016/j. ccr.2009.12.041.

7. Katsuyuki Miura, Hideaki Nakagawa, Hirotsugu Ueshima, Akira Okayama, Shikeyuki Saitoh, J. David Curb, Beatriz L. Rodriguez, et al., “Dietary Factors Related to Higher Plasma Fibrinogen Levels of Japanese-Americans in Hawaii Compared with Japanese in Japan,” Arteriosclerosis, Thrombosis, and Vascular Biology 26, no. 7 (July 2006): 1674–79, doi:10.1161/01. atv.0000225701.20965.b9.

8. Zeinab Tahmasebi Birgani, Nazli Gharraee, Angad Malhotra, Clemens A. Van Blitterswijk, and Pamela Habibovic, “Combinatorial Incorporation of Fluoride and Cobalt Ions into Calcium Phosphates to Stimulate Osteogenesis and Angiogenesis,” Biomedical Materials 11, no. 1 (February 29, 2016): 015020, doi:10.1088/1748-6041/11/1/015020.

9. Daniel J. Goldstein and Jose A. Halperin, “Mast Cell Histamine and Cell Dehydration Thirst,” Nature 267, no. 5608 (May 19, 1977): 250–52, doi:10.1038/267250a0.

10. Aletta D. Kraneveld, Seil Sagar, Johan Garssen, and Gert Folkerts, “The Two Faces of Mast Cells in Food Allergy and Allergic Asthma: The Possible Concept of Yin Yang,” Biochimica Et Biophysica Acta (BBA) 1822, no. 1 (January 2012): 93–99, doi:10.1016/j.bbadis.2011.06.013.

11. Liuliang Qin, Dezheng Zhao, Jianfeng Xu, Xianghui Ren, Ernest F. Terwilliger, Sareh Parangi, Jack Lawler, Harold F. Dvorak, and Huiyan Zeng, “The Vascular Permeabilizing Factors Histamine and Serotonin Induce Angiogenesis through TR3/Nur77 and Subsequently Truncate It through Thrombospondin-1,” Blood 121, no. 11 (March 14, 2013): 2154–164, doi:10.1182/blood-2012-07-443903.

12. Rebekah Beaton, Wendy Pagdin-Friesen, Christa Robertson, Cathy Vigar, Heather Watson, and Susan R. Harris, “Effects of Exercise Intervention on Persons with Metastatic Cancer: A Systematic Review,” Physiotherapy Canada 61, no. 3 (2009): 141–53, doi:10.3138/physio.61.3.141.

13. Centers for Disease Control and Prevention, “One in Five Adults Meet Overall Physical Activity Guidelines,” CDC Newsroom, May 2, 2013, https:// www.cdc.gov/media/releases/2013/p0502-physical-activity.html.

14. Steven C. Moore, I-Min Lee, and Elisabete Weiderpass, “Association of Leisure-Time Physical Activity with Risk of 26 Types of Cancer in 1.44 Million Adults,” JAMA Internal Medicine 176, no. 6 (June 1, 2016): 816–25, doi:10.1001/jamainternmed.2016.1548.

15. Huiqi Xie and Y. James Kang, “Role of Copper in Angiogenesis and Its Medicinal Implications,” Current Medicinal Chemistry 16, no. 10 (February 2009): 1304–14, doi:10.2174/092986709787846622.

16. Varsha P. Brahmkhatri, Chinmayi Prasanna, and Hanudatta S. Atreya, “Insulin-Like Growth Factor System in Cancer: Novel Targeted Therapies,” BioMed Research International 2015 (2015): 1–24, doi:10.1155/2015/538019.

17. Tian Lei and Xie Ling, “IGF-1 Promotes the Growth and Metastasis of Hepatocellular Carcinoma via the Inhibition of Proteasome-Mediated Cathepsin B Degradation,” World Journal of Gastroenterology 21, no. 35 (September 21, 2015): 10137–49, doi:10.3748/wjg.v21.i35.10137.

18. Chia-Wei Cheng, Gregor B. Adams, Laura Perin, Min Wei, Xiaoying Zhou, Ben S. Lam, Stefano Da Sacco, et al., “Prolonged Fasting Reduces IGF-1/PKA to Promote Hematopoietic-Stem-Cell-Based Regeneration and Reverse Immunosuppression,” Cell Stem Cell 14, no. 6 (June 5, 2014): 810–23, doi:10.1016/j.stem.2014.04.014.

19. Angela M. Poff, Csilla Ari, Thomas N. Seyfried, and Dominic P. D'Agostino, “The Ketogenic Diet and Hyperbaric Oxygen Therapy Prolong Survival in Mice with Systemic Metastatic Cancer,” PLOS ONE 8, no. 6 (June 5, 2013): e65522, doi:10.1371/journal.pone.0065522.

20. Charlotte Ornstein, “Popular Blood Thinner Causing Deaths, Injuries in Nursing Homes,” Washington Post, July 13, 2015. Available at https://www. pharmacist.com /popular-blood-thinner-causing-deaths-injuries-nursing-homes.

21. Caiguo Zhang, “Essential Functions of Iron-Requiring Proteins in DNA Replication, Repair and Cell Cycle Control,” Protein and Cell 5, no. 10 (October 2014): 750–60, doi:10.1007/s13238-014-0083-7.

22. “Micronutrient Deficiencies: Iron Deficiency Anaemia,” World Health Organization, accessed September 30, 2016, http://www.who.int/nutrition/ topics/ida/en.

23. Louis Harrison and Kimberly Blackwell, “Hypoxia and Anemia: Factors in Decreased Sensitivity to Radiation Therapy and Chemotherapy?” Oncologist 9, supplement 5 (November 2004): 31–40, doi:10.1634/ theoncologist.9-90005-31.

24. Janet R. Hunt, “Bioavailability of Iron, Zinc, and Other Trace Minerals from Vegetarian Diets,” American Journal of Clinical Nutrition 78, no. 3 (September 2003): 633s–39, http:// ajcn.nutrition.org/content/78/3/633S.full.

25. Adrian R. West, “Mechanisms of Heme Iron Absorption: Current Questions and Controversies,” World Journal of Gastroenterology 14, no. 26 (July 14, 2008): 41017–10, doi:10.3748/wjg.14.4101.

26. Ahmed A. Alkhateeb and James R. Connor, “The Significance of Ferritin in Cancer: Anti-Oxidation, Inflammation and Tumorigenesis,” Biochimica Et Biophysica Acta (BBA) 1836, no. 2 (December 2013): 245–54, doi:10.1016/j. bbcan.2013.07.002.

27. L. K. Ferrarelli, “Iron Fuels Glioblastoma Growth,” Science Signaling 8, no. 400 (October 27, 2015): ec311, doi:10.1126/scisignal.aad7099. 354 The Metabolic Approach to Cancer

28. Maria José Oliveira, Josef Van Damme, Tineke Lauwaet, Veerle De Corte, Georges De Bruyne, Gerda Verschraegen, et al., “β-Casein-Derived Peptides, Produced by Bacteria, Stimulate Cancer Cell Invasion and Motility,” EMBO Journal 22, no. 22 (November 17, 2003): 6161–73, doi:10.1093/emboj/ cdg586.

29. Gangjun Du, Lingtao Jin, Xiaofen Han, Zihui Song, Hongyan Zhang, and Wei Liang, “Naringenin: A Potential Immunomodulator for Inhibiting Lung Fibrosis and Metastasis,” Cancer Research 69, no. 7 (April 1, 2009): 3205–12, doi:10.1158/0008-5472.can-08-3393.

30. Hu Wang, Tin Khor, Limin Shu, Zheng-Yuan Su, Francisco F. Fuentes, Jong Hun Lee, and Ah-Ng Tony Kong, “Plants vs. Cancer: A Review on Natural Phytochemicals in Preventing and Treating Cancers and Their Druggability,” Anti-Cancer Agents in Medicinal Chemistry 12, no. 10 (May 2012): 1281–305, doi:10.2174/187152012803833026.

31. Ke Zu, Lorelei Mucci, Bernard A. Rosner, Steven K. Clinton, Massimo Loda, Meir J. Stampfer, and Edward Giovannucci, “Dietary Lycopene, Angiogenesis, and Prostate Cancer: A Prospective Study in the Prostate-Specific Antigen Era,” Journal of the National Cancer Institute 106, no. 2 (February 2014): djt430, doi:10.1093/jnci/djt430.

32. Daniel Man-Yuen Sze and Godfrey Chi-Fung Chan, “Effects of BetaGlucans on Different Immune Cell Populations and Cancers,” Advances in Botanical Research 62 (December 2012): 179–96, doi:10.1016/b978-0-12-394591-4.00011-8.

33. Jeong-Ki Min, “Capsaicin Inhibits in Vitro and in Vivo Angiogenesis,” Cancer Research 64, no. 2 (January 2004): 644–51, doi:10.1158/0008-5472. can-03-3250.

34. Jun Lv, Lu Qi, Canqing Yu, Ling Yang, Yu Guo, Yiping Chen, Zheng Bian, et al., “Consumption of Spicy Foods and Total and Cause Specific Mortality: Population Based Cohort Study,” BMJ 2015 (August 4, 2015): 351, doi:10.1136/bmj.h3942.

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36. Viktor Chesnokov, Chao Sun, and Keiichi Itakura, “Glucosamine Suppresses Proliferation of Human Prostate Carcinoma DU145 Cells through Inhibition of STAT3 Signaling,” Cancer Cell International 9, no. 1 (September 10, 2009): 25, doi:10.1186/1475-2867-9-25.

37. Maharjan H. Radha and Nampoothiri P. Laxmipriya, “Evaluation of Biological Properties and Clinical Effectiveness of Aloe vera: A Systematic Review,” Journal of Traditional and Complementary Medicine 5, no. 1 (December 23, 2014): 21–26, doi:10.1016/j.jtcme.2014.10.006.

38. Naghma Khan and Hasan Mukhtar, “Cancer and Metastasis: Prevention and Treatment by Green Tea,” Cancer and Metastasis Reviews 29, no. 3 (September 2010): 435–45, doi:10.1007/s10555-010-9236-1.

39. Shihong Chen, Zhijun Wang, Ying Huang, Stephen A. O'Barr, Rebecca A. Wong, Steven Yeung, and Moses Sing Sum Chow, “Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review,” Evidence-Based Complementary and Alternative Medicine 2014 (2014): 1–13, doi:10.1155/2014/168940.

40. é milie C. Lefort and Jonathan Blay, “Apigenin and Its Impact on Gastrointestinal Cancers,” Molecular Nutrition and Food Research 57, no. 1 (January 2013): 126–44, doi:10.1002/mnfr.201200424.

Глава 10. Жадные до гормонального баланса

1. Michael K. Brawer, “Testosterone Replacement in Men with Andropause: An Overview,” Reviews in Urology 6, supplement 6 (2004): s9–15, http://www. ncbi.nlm.nih.gov/pmc/articles/PMC1472881.

2. Robert H. Carlson, “Targeting Estrogen to Modulate Angiogenesis,” Oncology Times 29, no. 8 (April 25, 2007): 56, doi:10.1097/01. COT.0000269640.65146.7e.

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5. Petra Haag, Jasmin Bektic, Gerog Bartsch, Helmut Klocker, and Iris E. Eder, “Androgen Receptor Down Regulation by Small Interference RNA Induces Cell Growth Inhibition in Androgen Sensitive as well as in Androgen Independent Prostate Cancer Cells,” Journal of Steroid Biochemistry and Molecular Biology 96, no. 3–4 (August 2005): 251–58, doi:10.1016/j. jsbmb.2005.04.029.

6. Michelle Whirl-Carrillo, Ellen M. McDonagh, J. M. Hebert, Ii Chun Gong, K. Sangkuhl, C. F. Thorn, Russ B. Altman, and T. E. Klein, “Pharmacogenomics Knowledge for Personalized Medicine,” Clinical Pharmacology and Therapeutics 92, no. 4 (October 2012): 414–17, doi:10.1038/ clpt.2012.96.

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8. Heather Greenlee, Yu Chen, Geoffrey C. Kabat, Qiao Wang, Muhammad G. Kibriya, Irina Gurvich, Daniel W. Sepkovic, et al., “Variants in Estrogen Metabolism and Biosynthesis Genes and Urinary Estrogen Metabolites in Women with a Family History of Breast Cancer,” Breast Cancer Research and Treatment 102, no. 1 (March 2007): 111–17, doi:10.1007/s10549-006-9308-7.

9. H. L. Bradlow and M. A. Zeligs, “Diindolylmethane (DIM) Spontaneously Forms from Indole-3-Carbinol (I3C) during Cell Culture Experiments,” In Vivo 24, no. 4 (July/August 2010): 387–91, https://www.ncbi.nlm.nih.gov/ pubmed/20668304.

10. Chandradhar Dwivedi, Wendy J. Heck, Alan A. Downie, Saroj Larroya, and Thomas E. Webb, “Effect of Calcium Glucarate on β-glucuronidase Activity and Glucarate Content of Certain Vegetables and Fruits,” Biochemical Medicine and Metabolic Biology 43, no. 2 (1990): 83–92, doi:10.1016/0885-4505(90)90012-p.

11. L. D. Cowan, L. Gordis, J. A. Tonascia, and G. S. Jones, “Breast Cancer Incidence in Women with a History of Progesterone Deficiency,” American Journal of Epidemiology 114, no. 2 (August 1981): 209–17, https://www.ncbi. nlm.nih.gov/pubmed/7304556.

12. Reini W. Bretveld, Chris M. G. Thomas, Paul T. J. Scheepers, Gerhard A. Zielhuis, and Nel Roeleveld, “Pesticide Exposure: The Hormonal Function of the Female Reproductive System Disrupted?” Reproductive Biology and Endocrinology 4 (May 31, 2006): 30, doi:10.1186/1477-7827-4-30.

13. Hitomi Takemura, Harue Uchiyama, Takeshi Ohura, Hiroyuki Sakakibara, Ryoko Kuruto, Takashi Amagai, and Kayoko Shimoi, “A Methoxyflavonoid, Chrysoeriol, Selectively Inhibits the Formation of a Carcinogenic Estrogen Metabolite in MCF-7 Breast Cancer Cells,” Journal of Steroid Biochemistry and Molecular Biology 118, no. 1–2 (January 2010): 70–76, doi:10.1016/j.jsbmb.2009.10.002.

14. Romilly E. Hodges and Deanna M. Minich, “Modulation of Metabolic Detoxification Pathways Using Foods and Food-Derived Components: A Scientific Review with Clinical Application,” Journal of Nutrition and Metabolism 2015 (2015): 1–23, doi:10.1155/2015/760689.

15. Wendee Holtcamp, “Obesogens: An Environmental Link to Obesity,” Environmental Health Perspectives 120, no. 2 (February 2012): a62–68, doi:10.1289/ehp.120-a62.

16. Barbara Hammes and Cynthia J. Laitman, “Diethylstilbestrol (DES) Update: Recommendations for the Identification and Management of DESExposed Individuals,” Journal of Midwifery and Women's Health 48, no. 1 (January/February 2003): 19–29, doi:10.1016/s1526-9523(02)00370-7.

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18. Renée Johnson, “The US-EU Beef Hormone Dispute,” Congressional Research Service, January 14, 2015, https://fas.org/sgp/crs/row/R40449.pdf.

19. Y. Handa, H. Fujita, S. Honma, H. Minakami, and R. Kishi, “Estrogen Concentrations in Beef and Human Hormone-Dependent Cancers,” Annals of Oncology 20, no. 9 (July 23, 2009): 1610–11, doi:10.1093/annonc/mdp381.

20. V. Beral, D. Bull, R. Doll, T. Key, R. Peto, G. Reeves, E. E. Calle, et al., “Breast Cancer and Hormone Replacement Therapy: Collaborative Reanalysis of Data from 51 Epidemiological Studies of 52,705 Women with Breast Cancer and 108,411 Women without Breast Cancer,” Lancet 350, no. 9084 (October 11, 1997): 1047–59, doi:10.1016/S0140-6736(97)08233-0.

21. NIH, “WHI Follow Up Study Confirms Health Risks of Long-Term Combination Hormone Therapy Outweigh Benefits for Postmenopausal Women,” US National Library of Medicine, March 4, 2008, https://www.nih. gov/news-events/news-releases/whi-follow-study-confirms-health-risks-longterm-combination-hormone-therapy-outweigh-benefits-postmenopausal-women.

22. Jane Higdon, Victoria J. Drake, and David E. Williams, “Indole-3-Carbinol,” Micronutrient Information Center, Linus Pauling Instititue,Oregon State University, last updated December 2008, http://lpi.oregonstate.edu/mic/ dietary-factors/phytochemicals/indole-3-carbinol; Probo Y. Nugrahedi, Budi Midianarko, Matthijs Dekker, Ruud Vekerk, and Teresa Oliviero, “Retention of Glucosinolates during Fermentation of Brassica juncea: A Case Study on Production of Sayur Asin,” European Food Research and Technology 240, no. 3 (March 2015): 559–65, doi:10.1007/s00217-014-2355-0.

23. Neil McKinney, Naturopathic Oncology: An Encyclopedic Guide for Patients and Physicians (Richmond, BC: Creative Guy Publishing, 2010).

24. L. Bacciottini, Alberto Falchetti, B. Pampaloni, E. Bartolini, A. Carossino, and M. Brandi, “Phytoestrogens: Food or Drug?” chap. 24 in Andrea R. Genazzani, Postmenopausal Osteopoersis: Hormones and Other Therapies (Boca Raton, FL: CRC Press, 2006): 219–31, doi:10.1201/b14631-25.

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29. Fen-Jin He and Jin-Qiang Chen, “Consumption of Soybean, Soy Foods, Soy Isoflavones and Breast Cancer Incidence: Differences between Chinese Women and Women in Western Countries and Possible Mechanisms,” Food Science and Human Wellness 2, no. 3–4 (September – December 2013): 146–61, doi:10.1016/j.fshw.2013.08.002.

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33. Emir Bozkurt, Harika Atmaca, Asli Kisim, Selim Uzunoglu, Ruchan Uslu, and Burcak Karaca, “Effects of Thymus serpyllum Extract on Cell Proliferation, Apoptosis and Epigenetic Events in Human Breast Cancer Cells,” Nutrition and Cancer 64, no. 8 (November 19, 2012): 1245–50, doi:10.1080/0 1635581.2012.719658.

Глава 11. Стресс и циркадные ритмы

1. “2015 Stress in America Snapshot,” American Psychological Association, accessed November 22, 2016, http://www.apa.org/news/press/releases/ stress/2015/snapshot.aspx.

2. Myrthala Moreno-Smith, Susan K. Lutgendorf, and Anil K. Sood, “Impact of Stress on Cancer Metastasis,” Future Oncology 6, no. 12 (December 2010): 1863–81, doi:10.2217/fon.10.142.

3. Bo Christensen, “Melatonin Could Be an Overlooked Treatment for Cancer,” ScienceNordic, June 1, 2015, http://sciencenordic.com/melatonin-could-be-overlooked-treatment-cancer.

4. Angela Spivey, “Light Pollution: Light at Night and Breast Cancer Risk Worldwide,” Environmental Health Perspectives 118, no. 12 (December 2010): A525, doi:10.1289/ehp.118-a525.

5. Quentin Fottrell, “55 % of American Workers Don't Take All Their Paid Vacation,” MarketWatch, June 19, 2016, http://www.marketwatch.com/ story/55-of-american-workers-dont-take-all-their-paid-vacation-2016-06-15.

6. Torbjørn Elvsashagen, Linn B. Norborn, Per Ш. Pedersen, Sophia H. Quraishi, Atle Bjørnerud, Ulrik F. Malt, Inge R. Groote, and Lars T. Westlye, “Widespread Changes in White Matter Microstructure after a Day of Waking and Sleep Deprivation,” PLOS ONE 10, no. 5 (May 28, 2015): e0127351, doi:10.1371/journal.pone.0127351.

7. Sheldon Cohen, Denise Janicki-Deverts, William J. Doyle, Gregory E. Miller, Ellen Frank, Bruce S. Rabin, and Ronald B. Turner, “Chronic Stress, Glucocorticoid Receptor Resistance, Inflammation, and Disease Risk,” Proceedings of the National Academy of Science of the United States of America 109, no. 16 (April 17, 2012): 5995–99, doi:10.1073/pnas.1118355109.

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10. Sefirin Djiogue, Armel Hervé Nwabo Kamdje, Lorella Vecchio, Maulilio John Kipanyula, Mohammed Farahna, Yousef Aldebasi, and Paul Faustin Seke Etet, “Insulin Resistance and Cancer: The Role of Insulin and IGFs,” Endocrine-Related Cancer 20 no. 1 (February 1, 2013): R1–17, doi:10.1530/ERC-12-0324.

11. Afaf Girgis, Sylvie Lambert, Claire Johnson, Amy Waller, and David Currow, “Physical, Psychosocial, Relationship, and Economic Burden of Caring for People with Cancer: A Review,” Journal of Oncology Practice 9, no. 4 (July 2013): 197–202, doi:10.1200/jop.2012.000690.

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14. Zhigang Lu, Jingjing Xie, Guojin Wu, Jinhui Shen, Robert Collins, Weina Chen, Xunlei Kang, et al., “Fasting Selectively Blocks Development of Acute Lymphoblastic Leukemia via Leptin-Receptor Upregulation,” Nature Medicine 23 (December 2016): 79–90, doi:10.1038/nm.4252.

15. Daniel F. Kripke, Robert D. Langer, and Lawrence E. Kline, “Hypnotics' Association with Mortality or Cancer: A Matched Cohort Study,” BMJ Open 2, no. 1 (February 27, 2012): e00850, doi:10.1136/bmjopen-2012-000850.

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17. Lisa Chopin, Carina Walpole, Inge Seim, Peter Cunningham, Rachael Murray, Eliza Whiteside, Peter Josh, and Adrian Herington, “Ghrelin and Cancer,” Molecular and Cellular Endocrinology 340, no. 1 (June 20, 2011): 65–69, doi:10.1016/j.mce.2011.04.013.

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19. Erina Nakamura, Ken-ichi Kozaki, Hitoshi Tsuda, Emina Suzuki, Atiphan Pimkhaokham, Gou Yamamoto, Tarou Irie, et al., “Frequent Silencing of a Putative Tumor Suppressor Gene Melatonin Receptor 1 A (MTNR1A) in Oral Squamous-Cell Carcinoma,” Cancer Science 99, no. 7 (July 2008): 1390–400, doi:10.1111/j.1349–7006.2008.00838.x.

20. T. S. Wiley and Bent Formby, Lights Out: Sleep, Sugar, and Survival (New York: Pocket Books, 2000).

21. Antonio Cutando, Antonio López-Valverde, Salvador Arias-Santiago, Joaquin de Vicente Buendia, and Rafael Gómez de Diego, “Role of Melatonin in Cancer Treatment,” Anticancer Research 32, no. 7 (July 2012): 2747–53.

22. Russel J. Reiter, Du-Xian Tan, Rosa M. Sainz, Juan Carlos Mayo, Silvia Lopez-Burillo, “Melatonin: Reducing the Toxicity and Increasing the Efficacy of Drugs,” Journal of Pharmacy and Pharmacology 54, no. 10 (November 2002): 1299–321, doi:10.1211/002235702760345374.

23. J. Christian Gillin, “How Long Can Humans Stay Awake?” accessed November 15, 2016, https://www.scientificamerican.com/article/how-longcan-humans-stay.

24. Jennifer A. Mohawk, Carla Beth Green, and Joseph S. Takahashi, “Central and Peripheral Circadian Clocks in Mammals,” Annual Review of Neuroscience 35, no. 1 (April 2012): 445–62, doi:10.1146/annurev-neuro-060909-153128.

25. Saurabh Sahar and Paolo Sassone-Corsi, “Metabolism and Cancer: The Circadian Clock Connection,” Nature Reviews Cancer 9, no. 12 (December 2009): 886–96, doi:10.1038/nrc2747.

26. Jens Freese, Daniel J. Pardi, Begoňa Ruiz-NỨňez, Sebastian Schwarz, Regula Heynck, Robert Renner, Philipp Zimmer, and Helmut Lötzerich, “Back to the Future. Metabolic Effects of a 4-Day Outdoor Trip under Simulated Paleolithic Conditions – New Insights from The Eifel Study,” Journal of Evolution and Health 1, no. 1 (October 24, 2016):doi:10.15310/2334-3591.1035.

27. Mark P. Mattson, “Hormesis Defined,” Ageing Research Reviews 7, no. 1 (January 2008): 1–7, doi:10.1016/j.arr.2007.08.007.

28. Mark P. Mattson and Aiwu Cheng, “Neurohormetic Phytochemicals: Low-Dose Toxins That Induce Adaptive Neuronal Stress Responses,” Trends in Neurosciences 29, no. 11 (November 2006): 632–39, doi:10.1016/j. tins.2006.09.001.

29. Vikneswaran Murugaiyah and Mark P. Mattson, “Neurohormetic Phytochemicals: An Evolutionary-Bioenergetic Perspective,” Neurochemistry International 89 (October 2015): 271–80, doi:10.1016/j.neuint.2015.03.009.

30. Prasad R. Dandawate, Dharmalingam Subramaniam, Subhash B. Padhye, and Shrikant Anant, “Bitter Melon: A Panacea for Inflammation and Cancer,” Chinese Journal of Natural Medicines 14, no. 2 (February 2016): 81–100, doi:10.1016/S1875-5364(16)60002-X.

31. Kenneth G. Collins, Gerald F. Fitzgerald, Catherine Stanton, and R. Paul Ross, “Looking Beyond the Terrestrial: The Potential of Seaweed Derived Bioactives to Treat Non Communicable Diseases,” Marine Drugs 14, no. 3 (March 18, 2016), doi:10.3390/md14030060.

32. Alexander Panossian, Marina Hambardzumyan, Areg Hovhanissyan, and Georg Wikman, “The Adaptogens Rhodiola and Schizandra Modify the Response to Immobilization Stress in Rabbits by Suppressing the Increase of Phosphorylated Stress-Activated Protein Kinase, Nitric Oxide and Cortisol,” Drug Target Insights 2 (February 16, 2007): 39–54, http://www.ncbi.nlm.nih. gov/pmc/articles/PMC3155223.

33. Zhongbo Liu, Xuesen Li, Anne R. Simoneau, Mahtab Jafari, and Xiaolin Zi, “Rhodiola Rosea Extracts and Salidroside Decrease the Growth of Bladder Cancer Cell Lines via Inhibition of the mTOR Pathway and Induction of Autophagy,” Molecular Carcinogenesis 51, no. 3 (March 2012): 257–67, doi:10.1002/mc.20780.

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35. Tomohiro Shimizu, Marİa P. Torres, Subhankar Chakraborty, Joshua J. Souchek, Satyanarayana Rachagani, Sukhwinder Kaur, Muzafar Macha, et al., “Holy Basil Leaf Extract Decreases Tumorigenicity and Metastasis of Aggressive Human Pancreatic Cancer Cells in Vitro and in Vivo: Potential Role in Therapy,” Cancer Letters 336, no. 2 (August 19, 2013): 270–80, doi:10.1016/j. canlet.2013.03.017.

36. O. Igarashi, “The Significance of the Issuance of the 5th Revision of the Japanese Standard Tables of Food Components on Study and Research on Vitamins and Diseases,” 36th Vitamin Information Center Press Seminar, Tokyo, Japan, 2001.

37. Jo Robinson, Eating on the Wild Side: The Missing Link to Optimum Health (New York: Little, Brown and Company, 2013).

Глава 12. Психическое и эмоциональное благополучие

1. Michael K. Skinner and Carlos Guerrero-Bosagna, “Environmental Signals and Transgenerational Epigenetics,” Epigenomics 1, no. 1 (October 2009): 111–117, doi:10.2217/epi.09.11.

2. Thomas Jessy, “Immunity Over Inability: The Spontaneous Regression of Cancer,” Journal of Natural Science, Biology, and Medicine 2, no. 1 (January 2011): 43–49, doi:10.4103/0976-9668.82318.

3. Jerome Sarris, Alan C. Logan, Tasnime N. Akbaraly, G. Paul Amminger, Vicent Balanzá – Martİ nez, Marlene P. Freeman, Joseph Hibbeln, et al., “Nutritional Medicine as Mainstream in Psychiatry,” Lancet Psychiatry 2, no. 3 (March 2015): 271–74, doi:10.1016/S2215-0366(14)00051-0.

4. Pedro Rada, N. M. Avena, and B. G. Hoebel, “Daily Bingeing on Sugar Repeatedly Releases Dopamine in the Accumbens Shell,” Neuroscience 134, no. 3 (February 2005): 737–44, doi:10.1016/j.neuroscience.2005.04.043.

5. UCSF Benoiff Children's Hospital Oakland, “Omega-3 Fatty Acids, Vitamin D May Control Brain Serotonin, Affecting Behavior and Psychiatric Disorders,” ScienceDaily, February 25, 2015, https://www.sciencedaily.com/ releases/2015/02/150225094109.htm.

6. Liang-Jen Wang, Sheng-Yu Lee, Shiou-Lan Chen, Yun-Hsuan Chang, Po See Chen, San-Yuan Huang, Nian-Sheng Tzeng, et al., “A Potential Interaction between COMT and MTHFR Genetic Variants in Han Chinese Patients with Bipolar II Disorder,” Scientific Reports 5 (March 6, 2015): 8813, doi:10.1038/srep08813.

7. Simon N. Young, “Folate and Depression – A Neglected Problem,” Journal of Psychiatry and Neuroscience 32, no. 2 (March 2007): 80–82, http:// www.ncbi.nlm.nih.gov/pmc/articles/PMC1810582.

8. NIH, “COMT Gene,” Genetics Home Reference, January 24, 2017, https://ghr.nlm.nih.gov/gene/COMT.

9. H. J. Baltrusch, W. Stangel, and I. Titze, “Stress, Cancer and Immunity. New Developments in Biopsychosocial and Psychoneuroimmunologic Research,” Acta Neurolgical (Napoli) 13, no. 4 (August 1991): 315–27, https:// ncbi.nlm.nih.gov/labs/articles/1781308.

10. M. A. Visintainer, J. R. Volpicelli, and M. E. P. Seligman, “Tumor Rejection in Rats after Inescapable or Escapable Shock,” Science 216, no. 4544 (May 1982): 437–39, doi:10.1126/science.7200261.

11. Marilia Carabotti, Annunziata Scirocco, Maria Antonietta Maselli, and Carola Severi, “The Gut-Brain Axis: Interactions between Enteric Microbiota, Central and Enteric Nervous Systems,” Annals of Gastroenterology 28, no. 2 (April – June 2015): 203–9, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367209.

12. Anastasiya Slyepchenko, Andre F. Carvalho, Danielle S. Cha, Siegfried Kasper, and Roger S. McIntyre, “Gut Emotions – Mechanisms of Action of Probiotics as Novel Therapeutic Targets for Depression and Anxiety Disorders,” CNS and Neurological Disorders Drug Targets 13, no. 10 (2014): 1770–86.

13. Liya Qin, Xuefei Wu, Michelle L. Block, Yuxin Liu, George R. Breese, Jau-Shyong Hong, Darin J. Knapp, and Fulton T. Crews, “Systemic LPS Causes Chronic Neuroinflammation and Progressive Neurodegeneration,” Glia 55, no. 5 (April 1, 2007): 453–62, doi:10.1002/glia.20467.

14. A. E. Kalaydjian, W. Eaton, N. Cascella, and A. Fasano, “The Gluten Connection: The Association between Schizophrenia and Celiac Disease,” Acta Psychiatrica Scandinavica 113, no. 2 (February 2006): 82–90, doi:10.1111/ j.1600–0447.2005.00687.x.

15. Wanyi Tai, Zhijin Chen, and Kun Cheng, “Expression Profile and Functional Activity of Peptide Transporters in Prostate Cancer Cells,” Molecular Pharmaceutics 10, no. 2 (February 4, 2013): 477–87. doi:10.1021/mp300364k.

16. Sandra Zoghbi, Aurelien Trompette, Jean Claustre, Mahmoud El Homsi, Javier Garzón, Gérard Jourdan, Jean-Yves Scoazec, and Pascale Plaisancie, “β-Casomorphin-7 Regulates the Secretion and Expression of Gastrointestinal Mucins through a μ-Opioid Pathway,” American Journal of Physiology – Gastrointestinal and Liver Physiology 290, no. 6 (May 10, 2006): G1105–1, doi:10.1152/ajpgi.00455.2005; Katarzyna Gach, Anna Wyrebska, Jakub Fichna, and Anna Janecka, “The Role of Morphine in Regulation of Cancer Cell Growth,” Naunyn-Schmiedeberg's Archives of Pharmacology 384, no. 3 (September 2011): 221–30, doi:10.1007/s00210-011-0672-4.

17. Richard J. Farrell and Ciarán P. Kelly, “Celiac Sprue,” New England Journal of Medicine 346, no. 3 (January 17, 2002): 180–88, doi:10.1056/ NEJMra010852.

18. Flore Depeint, W. Robert Bruce, Nandita Shangari, Rhea Mehta, and Peter J. O'Brien, “Mitochondrial Function and Toxicity: Role of the B Vitamin Family on Mitochondrial Energy Metabolism,” Chemico-Biological Interactions 163, no. 1–2 (November 2006): 94–112, doi:10.1016/j.cbi.2006.04.014.

19. Edward H. Tobe, “Mitochondrial Dysfunction, Oxidative Stress, and Major Depressive Disorder,” Neuropsychiatric Disease and Treatment 9 (2013): 567–73, doi:10.2147/NDT.S44282.

20. Pál Pacher, Sándor Bátkai, and George Kunos, “The Endocannabinoid System as an Emerging Target of Pharmacotherapy,” Pharmacological Reviews 58, no. 3 (September 2006): 389–462, doi:10.1124/pr.58.3.2.

21. Karl W. Hillig and Paul G. Mahlberg, “A Chemotaxonomic Analysis of Cannabinoid Variation in Cannabis (Cannabaceae),” American Journal of Botany 91, no. 6 (June 2004): 966–75, doi:10.3732/ajb.91.6.966.

22. Lifang Mao, Suizhen Lin, and Jun Lin, “The Effects of Anesthetics on Tumor Progression,” International Journal of Physiology, Pathophysiology and Pharmacology 5, no. 1 (March 8, 2013): 1–10, http://www.ncbi.nlm.nih.gov/ pmc/articles/PMC3601457.

23. Paola Massi, Marta Solinas, Valentina Cinquina, and Daniela Parolaro, “Cannabidiol as Potential Anticancer Drug,” British Journal of Clinical Pharmacology 75, no. 2 (February 2013): 303–12, doi:10.1111/j.1365–2125.2012.04298.x.

24. D. I. Abrams and M. Guzman, “Cannabis in Cancer Care,” Clinical Pharmacology and Therapeutics 97, no. 6 (June 2015): 575–86, doi:10.1002/ cpt.108.

25. Hong-Fang Ji, Xue-Juan Li, and Hong-Yu Zhang, “Natural Products and Drug Discovery: Can Thousands of Years of Ancient Medical Knowledge Lead Us to New and Powerful Drug Combinations in the Fight against Cancer and Dementia?” EMBO Reports 10, no. 3 (March 2009): 194–200, doi:10.1038/ embor.2009.12.

26. V. Di Marzo, “The Endocannabinoid System in Obesity and Type 2 Diabetes,” Diabetologia 51 (June 18, 2008): 1356–67, doi:10.1007/s00125-008-1048-2. Available at http://theroc.us/images/The%20endocannabinoid%20 system%20in%20obesity%20and%20type%202%20diabetes.pdf.

Глава 13. Налаживаем связь между всеми элементами среды на кухне

1. William Davis, Wheat Belly: Lose the Wheat, Lose the Weight, and Find Your Path Back to Health (Emmaus, PA: Rodale, 2011).

2. James R. Roberts, Catherine J. Karr, Jerome A. Paulson, Alice C. Brock-Utne, Heather Brumber, Carla C. Campbell, Bruce P. Lanphear, et al., “Pesticide Exposure in Children,” Pediatrics 130, no. 6 (December 2012): e1757–63, doi:10.1542/peds.2012–2757.

3. W. R. Phipps, M. C. Martini, J. W. Lampe, J. L. Slavin, and M. S. Kurzer, “Effect of Flax Seed Ingestion on the Menstrual Cycle,” Journal of Clinical Endocrinology and Metabolism 77, no. 5 (November 1993): 1215–19, doi:10.1210/jcem.77.5.8077314.

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