Книга: Сумма биотехнологии. Руководство по борьбе с мифами о генетической модификации растений, животных и людей
Назад: Благодарности
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Список литературы
1. Lazaris A. et al.: Spider silk fibers spun from soluble recombinant silk produced in mammalian cells. Science 2002, 295(5554):472–6.
2. Wen H. et al.: Transgenic silkworms (Bombyx mori) produce recombinant spider dragline silk in cocoons. Mol Biol Rep 2010, 37(4):1815–21.
3. Gomes S.C. et al.: Antimicrobial functionalized genetically engineered spider silk. Biomaterials 2011, 32(18):4255–66.
4. Maga E.A. et al.: Human lysozyme expressed in the mammary gland of transgenic dairy goats can inhibit the growth of bacteria that cause mastitis and the cold-spoilage of milk. Foodborne Pathog Dis 2006, 3(4):384–92.
5. Wang L.S., Stoner G.D.: Anthocyanins and their role in cancer prevention. Cancer Lett 2008, 269(2):281–90.
6. Toufektsian M.C. et al.: Chronic dietary intake of plantderived anthocyanins protects the rat heart against ischemia-reperfusion injury. J Nutr 2008, 138(4):747–52.
7. Tsuda T. et al.: Dietary cyanidin 3-O-beta-D-glucoside-rich purple corn color prevents obesity and ameliorates hyperglycemia in mice. J Nutr 2003, 133(7):2125–30.
8. Butelli E. et al.: Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors. Nat Biotechnol 2008, 26(11):1301–8.
9. Walsh G.: Therapeutic insulins and their large-scale manufacture. Appl. Microbiol Biotechnol 2005, 67(2):151–9.
10. Pipe S.W.: Recombinant clotting factors. Thromb Haemost 2008, 99(5):840–50.
11. Baxter L. et al.: Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev 2007(1):CD003887.
12. Hillman J.D. et al.: Modification of an effector strain for replacement therapy of dental caries to enable clinical safety trials. Appl Microbiol 2007, 102(5):1209–19.
13. Chen Z. et al.: Incorporation of therapeutically modified bacteria into gut microbiota inhibits obesity. J Clin Invest 2014, 124(8):3391–406.
14. Fedosov S.N. et al.: Human intrinsic factor expressed in the plant Arabidopsis thaliana. Eur J Biochem 2003, 270(16):3362–7.
15. Stein L. et al.: Clinical gene therapy for the treatment of RPE65-associated Leber congenital amaurosis. Expert Opin Biol Ther 2011, 11(3):429–39.
16. Gaspar H.B. et al.: Long-term persistence of a polyclonal T cell repertoire after gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med 2011, 3(97):97ra79.
17. Brentjens R.J. et al.: CD19-targeted T cells rapidly induce molecular remissions in adults with chemotherapy-refractory acute lymphoblastic leukemia. Sci Transl Med 2013, 5(177):177ra38.
18. Forsberg C.W. et al.: Integration, stability and expression of the E. coli phytase transgene in the Cassie line of Yorkshire Enviropig. Transgenic Res 2013, 22(2):379–89.
19. Callaway E.: Glowing plants spark debate. Nature 2013, 498(7452):15–6.
20. Marcus J.M. et al.: Germline transformation of the butterfly Bicyclus anynana. Proc Biol Sci 2004, 271 Suppl 5:S263–5.
21. Ormandy E.H. et al.: Genetic engineering of animals: ethical issues, including welfare concerns. Can Vet J 2011, 52(5):544–50.
22. Clark S. et al.: Frequency of US emergency department visits for food-related acute allergic reactions. J Allergy Clin Immunol 2011, 127(3):682–3.
23. Gilissen L.J. et al.: Silencing the major apple allergen Mald 1 by using the RNA interference approach. J Allergy Clin Immunol 2005, 115(2):364–9.
24. Gulland A.: Average daily consumption of sugar must be halved, says WHO. BMJ 2014, 348:g2003.
25. Zemanek E.C., Wasserman B.P.: Issues and advances in the use of transgenic organisms for the production of thaumatin, the intensely sweet protein from Thaumatococcus danielli. Crit Rev Food Sci Nutr 1995, 35(5):455–66.
26. Mahdavi F. et al.: Expression of rice thaumatin-like protein gene in transgenic banana plants enhances resistance to fusarium wilt. Appl Biochem Biotechnol 2012, 166(4):1008–19.
27. Rothemund P.W.: Folding DNA to create nanoscale shapes and patterns. Nature 2006, 440(7082):297–302.
28. Zadegan R.M. et al.: Construction of a 4 zeptoliters switchable 3D DNA box origami. ACS Nano 2012, 6(11):10050–3.
29. Thrall P.H. et al.: Evolutionary change in agriculture: the past, present and future. Evol Appl 2010, 3(5–6):405–8.
30. Klumper W., Qaim M.: A meta-analysis of the impacts of genetically modified crops. PLOS ONE 2014, 9(11):e111629.
31. Fernandez-Cornejo J. et al.: Genetically Engineered Crops in the United States. United States Department of Agriculture 2014, Economic Research Report Number 162.
32. Lu Y. et al.: Widespread adoption of Bt cotton and insecticide decrease promotes biocontrol services. Nature 2012, 487(7407):362–5.
33. Tripathi S. et al.: Papaya ringspot virus-P: characteristics, pathogenicity, sequence variability and control. Mol Plant Pathol 2008, 9(3):269–80.
34. Neilson R.: Proposals for the future regulation of biotechnology in Australia. Melb Univ Law Rev 1992, 18(3):692–8.
35. Cohen S.N., Chang A.C.: Recircularization and autonomous replication of a sheared R-factor DNA segment in Escher ichia coli transformants. Proc Natl Acad Sci USA 1973, 70(5):1293–7.
36. Jaenisch R., Mintz B.: Simian virus 40 DNA sequences in DNA of healthy adult mice derived from preimplantation blastocysts injected with viral DNA. Proc Natl Acad Sci U S A 1974, 71(4):1250–4.
37. Fraley R.T. et al.: Expression of bacterial genes in plant cells. Proc Natl Acad Sci USA 1983, 80(15):4803–7.
38. Witthoft M., Rubin G.J.: Are media warnings about the adverse health effects of modern life self-fulfilling? An experimental study on idiopathic environmental intolerance attributed to electromagnetic fields (IEI-EMF). J Psychosom Res 2013, 74(3):206–12.
39. Zubieta J.K., Stohler C.S.: Neurobiological mechanisms of placebo responses. Ann NY Acad Sci 2009, 1156:198–210.
40. McMillan F.D.: The placebo effect in animals. J Am Vet Med Assoc 1999, 215(7):992–9.
41. Munana K.R. et al.: Placebo effect in canine epilepsy trials. J Vet Intern Med 2010, 24(1):166–70.
42. Zulkifli I.: Review of human-animal interactions and their impact on animal productivity and welfare. J Anim Sci Biotechnol 2013, 4(1):25.
43. de Craen A.J. et al.: Effect of colour of drugs: systematic review of perceived effect of drugs and of their effectiveness. BMJ 1996, 313(7072):1624–6.
44. Waber R.L. et al.: Commercial features of placebo and therapeutic efficacy. JAMA 2008, 299(9):1016–7.
45. Bjorkedal E., Flaten M.A.: Interaction between expectancies and drug effects: an experimental investigation of placebo analgesia with caffeine as an active placebo. Psychopharmacology (Berl) 2011, 215(3):537–48.
46. Purves D. et al.: Neuroscience. 2001.
47. Hrobjartsson A., Gotzsche P.C.: Placebo interventions for all clinical conditions. Cochrane Database Syst Rev 2010(1):CD003974.
48. McDonald C.J. et al.: How much of the placebo ‘effect’ is really statistical regression? Stat Med 1983, 2(4):417–27.
49. Benson H. et al.: Study of the Therapeutic Effects of Intercessory Prayer (STEP) in cardiac bypass patients: a multicenter randomized trial of uncertainty and certainty of receiving intercessory prayer. Am Heart J 2006, 151(4):934–42.
50. Kwok R.H.: Chinese-restaurant syndrome. N Engl J Med 1968, 278(14):796.
51. Tarasoff L., Kelly M.F.: Monosodium L-glutamate: a doubleblind study and review. Food Chem Toxicol 1993, 31(12):1019–35.
52. Geha R.S. et al.: Review of alleged reaction to monosodium glutamate and outcome of a multicenter double-blind placebo-controlled study. J Nutr 2000, 130(4S Suppl):1058S-62S.
53. Ye X. et al.: Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. Science 2000, 287(5451):303–5.
54. Romer S. et al.: Elevation of the provitamin A content of transgenic tomato plants. Nat Biotechnol 2000, 18(6):666–9.
55. Paine J.A. et al.: Improving the nutritional value of Golden Rice through increased pro-vitamin A content. Nat Biotechnol 2005, 23(4):482–7.
56. http://www.levada.ru/sites/default/files/shuvalova_o._otnoshenie_naseleniya_k_nauke.pdf
57. Buchholz U. et al.: German outbreak of Escherichia coli O104:H4 associated with sprouts. N Engl J Med 2011, 365(19):1763–70.
58. King L.A. et al.: Outbreak of Shiga toxin-producing Escherichia coli O104:H4 associated with organic fenugreek sprouts, France, June 2011. Clin Infect Dis 2012, 54(11):1588–94.
59. Oliveira M. et al.: Microbiological quality of fresh lettuce from organic and conventional production. Food Microbiol 2010, 27(5):679–84.
60. Wetzel K. et al.: Comparison of microbial diversity of edible flowers and basil grown with organic versus conventional methods. Can J Microbiol 2010, 56(11):943–51.
61. Fineschi V. et al.: Histological criteria for diagnosis of amanita phalloides poisoning. J Forensic Sci 1996, 41(3):429–32.
62. Kiran K.S., Padmaja G.: Inactivation of trypsin inhibitors in sweet potato and taro tubers during processing. Plant Foods Hum Nutr 2003, 58(2):153–63.
63. Freestone P.S. et al.: Acute action of rotenone on nigral dopaminergic neurons – involvement of reactive oxygen species and disruption of Ca2+ homeostasis. Eur J Neurosci 2009, 30(10):1849–59.
64. Gao H.M. et al.: Critical role for microglial NADPH oxidase in rotenone-induced degeneration of dopaminergic neurons. J Neurosci 2003, 23(15):6181–7.
65. Pan-Montojo F. et al.: Progression of Parkinson’s disease pathology is reproduced by intragastric administration of rotenone in mice. PLOS ONE 2010, 5(1):e8762.
66. Xu X. et al.: Natural pesticide dihydrorotenone arrests human plasma cancer cells at the G0/G1 phase of the cell cycle. J Biochem Mol Toxicol 2014, 28(5):232–8.
67. Simeone V. et al.: Residues of rotenone, azadirachtin, pyrethrins and copper used to control Bactrocera oleae (Gmel.) in organic olives and oil. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2009, 26(4):475–81.
68. Ames B.N. et al.: Dietary pesticides (99.99 % all natural). Proc Natl Acad Sci USA 1990, 87(19):7777–81.
69. Korpan Y.I. et al.: Potato glycoalkaloids: true safety or false sense of security? Trends in biotechnology 2004, 22(3):147–51.
70. Akeley R. et al.: Lenape: A new potato variety high in solids and chipping quality. Am Potato J 1968, 45(142–145).
71. Zitnak A., Johnston G.: Glycoalkaloid content of B5141–6 potatoes. Am Potato J 1970, 47:256–60.
72. HellanÄs K. et al.: High levels of glycoalkaloids in the established Swedish potato variety Magnum Bonum. J Sci Food Agric 1995, 68(249–255.).
73. Laurila J. et al.: Formation of parental type and novel alkaloids in somatic hybrids between Solanum brevidens and S. tuberosum. Plant Sci 1996, 118:145–55.
74. Watson J.D., Crick F.H.: Molecular structure of nucleic acids; a structure for deoxyribose nucleic acid. Nature 1953, 171(4356):737–8.
75. Pauling L., Corey R.B.: A Proposed Structure For The Nucleic Acids. Proc Natl Acad Sci U S A 1953, 39(2):84–97.
76. Karpov S.A. et al.: Obligately phagotrophic aphelids turned out to branch with the earliest-diverging fungi. Protist 2013, 164(2):195–205.
77. Sanchez-Silva R. et al.: A new noncanonical nuclear genetic code: translation of UAA into glutamate. Curr Biol 2003, 13(5):442–7.
78. Wang L. et al.: Expanding the genetic code of Escherichia coli. Science 2001, 292(5516):498–500.
79. Fiers W. et al.: Complete nucleotide sequence of bacteriophage MS2 RNA: primary and secondary structure of the replicase gene. Nature 1976, 260(5551):500–7.
80. International Human Genome Sequencing C: Finishing the euchromatic sequence of the human genome. Nature 2004, 431(7011):931–45.
81. Leitch I.J.: Genome sizes through the ages. Heredity (Edinb) 2007, 99(2):121–2.
82. Goff S.A. et al.: A draft sequence of the rice genome (Oryza sativa L. ssp. japonica). Science 2002, 296(5565):92–100.
83. Carlton J.M. et al.: Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science 2007, 315(5809):207–12.
84. Ohno S.: So much “junk” DNA in our genome. 23058793 1972, 23: 366–70.
85. Adzhubei I. et al.: Predicting functional effect of human missense mutations using PolyPhen-2. Curr Protoc Hum Genet 2013, Chapter 7:Unit7 20.
86. Rands C.M. et al.: 8.2 % of the Human genome is constrained: variation in rates of turnover across functional element classes in the human lineage. PLoS Genet 2014, 10(7):e1004525.
87. Meader S. et al.: Massive turnover of functional sequence in human and other mammalian genomes. Genome Res 2010, 20(10):1335–43.
88. Ebersberger I. et al.: Genomewide comparison of DNA sequences between humans and chimpanzees. Am J Hum Genet 2002, 70(6):1490–7.
89. Fraser C.M. et al.: The minimal gene complement of Mycoplasma genitalium. Science 1995, 270(5235):397–403.
90. Ratner L. et al.: Complete nucleotide sequence of the AIDS virus, HTLV–III. Nature 1985, 313(6000):277–84.
91. Philippe N. et al.: Pandoraviruses: amoeba viruses with genomes up to 2.5 Mb reaching that of parasitic eukaryotes. Science 2013, 341(6143):281–6.
92. Suzan-Monti M. et al.: Genomic and evolutionary aspects of Mimivirus. Virus Res 2006, 117(1):145–55.
93. Ou C.Y. et al.: Molecular epidemiology of HIV transmission in a dental practice. Science 1992, 256(5060):1165–71.
94. Toups M.A. et al.: Origin of clothing lice indicates early clothing use by anatomically modern humans in Africa. Mol Biol Evol 2011, 28(1):29–32.
95. Levy S. et al.: The diploid genome sequence of an individual human. PLOS Biol 2007, 5(10):e254.
96. Griffith F.: The Significance of Pneumococcal Types. The Journal of hygiene 1928, 27(2):113–59.
97. Avery O.T. et al.: Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type Iii. The Journal of experimental medicine 1944, 79(2):137–58.
98. Overballe-Petersen S. et al.: Bacterial natural transformation by highly fragmented and damaged DNA. Proceedings of the National Academy of Sciences of the United States of America 2013, 110(49):19860–5.
99. Taleb N. et al.: The Precautionary Principle (with Application to the Genetic Modification of Organisms). EXTREME RISK INITIATIVE – NYU SCHOOL OF ENGINEERING WORKING PAPER SERIES 2014.
100. Berner R.A.: Atmospheric oxygen over Phanerozoic time. Proc Natl Acad Sci U S A 1999, 96(20):10955–7.
101. Schloss P.D., Handelsman J.: Status of the microbial census. Microbiol Mol Biol Rev 2004, 68(4):686–91.
102. Sears C.L.: A dynamic partnership: celebrating our gut flora. Anaerobe 2005, 11(5):247–51.
103. Kong A. et al.: Rate of de novo mutations and the importance of father’s age to disease risk. Nature 2012, 488(7412):471–5.
104. Kunkel T.A.: Evolving views of DNA replication (in)fidelity. Cold Spring Harb Symp Quant Biol 2009, 74:91–101.
105. Bostanci A.: Wildlife biology. A devil of a disease. Science 2005, 307(5712):1035.
106. Rebbeck C.A. et al.: Origins and evolution of a transmissible cancer. Evolution 2009, 63(9):2340–9.
107. Villeneuve P.J., Mao Y.: Lifetime probability of developing lung cancer, by smoking status, Canada. Can J Public Health 1994, 85(6):385–8.
108. Nelson P.N. et al.: Human endogenous retroviruses: transposable elements with potential? Clin Exp Immunol 2004, 138(1):1–9.
109. Mi S. et al.: Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis. Nature 2000, 403(6771):785–9.
110. McClintock B.: The origin and behavior of mutable loci in maize. Proc Natl Acad Sci USA 1950, 36(6):344–55.
111. Kasahara M. et al.: On the origins of the adaptive immune system: novel insights from invertebrates and cold-blooded vertebrates. Trends Immunol 2004, 25(2):105–11.
112. Holland L.Z. et al.: The amphioxus genome illuminates vertebrate origins and cephalochordate biology. Genome Res 2008, 18(7):1100–11.
113. Kapitonov V.V., Jurka J.: RAG1 core and V(D)J recombination signal sequences were derived from Transib transposons. PLoS Biol 2005, 3(6):e181.
114. Panchin Y., Moroz L.L.: Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes. Biochem Biophys Res Commun 2008, 369(3):818–23.
115. Tonegawa S.: Somatic generation of antibody diversity. Nature 1983, 302(5909):575–81.
116. Jolly C.J., Neuberger M.S.: Somatic hypermutation of immunoglobulin kappa transgenes: association of mutability with demethylation. Immunol Cell Biol 2001, 79(1):18–22.
117. Makarova K.S. et al.: Evolution and classification of the CRISPR-Cas systems. Nat Rev Microbiol 2011, 9(6):467–77.
118. Kyndt T. et al.: The genome of cultivated sweet potato contains Agrobacterium T-DNAs with expressed genes: An example of a naturally transgenic food crop. Proc Natl Acad Sci U S A 2015.
119. Matveeva T.V. et al.: Horizontal gene transfer from genus agrobacterium to the plant linaria in nature. Mol Plant Microbe Interact 2012, 25(12):1542–51.
120. Nikoh N. et al.: Wolbachia genome integrated in an insect chromosome: evolution and fate of laterally transferred endosymbiont genes. Genome Res 2008, 18(2):272–80.
121. Crisp A. et al.: Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes. Genome Biol 2015, 16(1):50.
122. Zheng P. et al.: A phenylalanine in DGAT is a key determinant of oil content and composition in maize. Nat Genet 2008, 40(3):367–72.
123. Krishna V. et al.: Transgenic crops, production risk and agrobiodiversity. Eur Rev Agric Econ 2015.
124. Retraction notice to “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize” [Food Chem. Toxicol. 50 (2012) 4221–4231]. Food Chem Toxicol 2014, 63:244.
125. Seralini G.E. et al.: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem Toxicol 2012, 50(11):4221–31.
126. Langridge P.: Problems lie at several levels and bring into serious question the quality and standard of the editorial processes in your journal. Food Chem Toxicol 2013, 53:441.
127. Le Tien D., Le Huy H.: Comments on “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize”. Food Chem Toxicol 2013, 53:443–4.
128. GrÜnewald W., Bury J.: Comment on “Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize” by Seralini et al. Food Chem Toxicol 2013, 53:447–8.
129. Barale-Thomas E.: The SFPT feels compelled to point out weaknesses in the paper by Seralini et al. (2012). Food Chem Toxicol 2013, 53:473–4.
130. Berry C.: Adverse effects in a feeding study of a GM derived corn in rats. Food Chem Toxicol 2013, 53:445–6.
131. Tester M.: It does not become the quality of a journal such as Food and Chemical Toxicology to publish such poor work. Food Chem Toxicol 2013, 53:457.
132. Schorsch F.: Serious inadequacies regarding the pathology data presented in the paper by Seralini et al. (2012). Food Chem Toxicol 2013, 53:465–6.
133. Tribe D.: My comments about the paper do not adequately describe the serious failures that have occurred in the peer review process at FCT. Food Chem Toxicol 2013, 53:467–72.
134. Robert W. et al.: We request a serious reconsideration of the recent paper by Seralini et al. alleging tumorigenesis in rats resulting from consumption of corn derived from crops improved through biotechnology (Seralini et al., 2012). Food Chem Toxicol 2013, 53:455–6.
135. Sanders D. et al.: Re: Seralini, G.-E., et al. Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem. Toxicol. (2012). Food Chem Toxicol 2013, 53:450–3.
136. Ollivier L.: A comment on Seralini, G.-E., et al., Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem. Toxicol. (2012), http://dx.doi.org/10.1016/j.fct.2012.08.005. Food Chem Toxicol 2013, 53:458.
137. Trewavas A.: Science requires the dispassionate presentation of information. Food Chem Toxicol 2013, 53:449.
138. Portier C.J. et al.: Inconclusive findings: now you see them, now you don’t! Environ Health Perspect 2014, 122(2):A36.
139. de Souza L., Macedo Oda L.: Long term toxicity of a Roundup herbicide and a Roundup-tolerant genetically modified maize. Food Chem Toxicol 2013, 53:440.
140. Panchin A.Y.: Toxicity of Roundup-tolerant genetically modified maize is not supported by statistical tests. Food Chem Toxicol 2013, 53:475.
141. Heinemann J.A.: Food and chemical toxicology. Food Chem Toxicol 2013, 53:442.
142. Bennett C. et al.: Neural Correlates of Interspecies Perspective Taking in the Post-Mortem Atlantic Salmon: An Argument For Proper Multiple Comparisons Correction. Journal of Serendipitous and Unexpected Results 2010, 1(1):1–5.
143. Abdi H.: The Bonferonni and Šidák Corrections for Multiple Comparisons. Encyclopedia of Measurement and Statistics 2007.
144. Armstrong R.: When to use the Bonferroni correction. Ophthalmic and Physiological Optics 2014, 34(5):502–8.
145. Davenas E. et al.: Human basophil degranulation triggered by very dilute antiserum against IgE. Nature 1988, 333(6176):816–8.
146. Maddox J. et al.: “High-dilution” experiments a delusion. Nature 1988, 334(6180):287–91.
147. Ewen S.W., Pusztai A.: Effect of diets containing genetically modified potatoes expressing Galanthus nivalis lectin on rat small intestine. Lancet 1999, 354(9187):1353–4.
148. Miyake K. et al.: Lectin-based food poisoning: a new mechanism of protein toxicity. PLOS ONE 2007, 2(8):e687.
149. Cordain L. et al.: Modulation of immune function by dietary lectins in rheumatoid arthritis. Br J Nutr 2000, 83(3):207–17.
150. Zhang J. et al.: Pest control. Full crop protection from an insect pest by expression of long double-stranded RNAs in plastids. Science 2015, 347(6225):991–4.
151. Kuiper H.A. et al.: Adequacy of methods for testing the safety of genetically modified foods. Lancet 1999, 354(9187):1315–6.
152. Enserink M.: Transgenic food debate. The Lancet scolded over Pusztai paper. Science 1999, 286(5440):656.
153. Xu W. et al.: Analysis of caecal microbiota in rats fed with genetically modified rice by real-time quantitative PCR. J Food Sci 2011, 76(1):M88–93.
154. Carman J. et al.: A long-term toxicology study on pigs fed a combined genetically modified (GM) soy and GM maize diet. Journal of Organic Systems 2013, 8(1):38–54.
155. Bohn T. et al.: Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans. Food Chem 2014, 153:207–15.
156. Korsaeth A. et al.: Comments on the recently published study: “Compositional differences in soybeans on the market: glyphosate accumulates in Roundup Ready GM soybeans”, by T. Bohn, M. Cuhra, T. Traavik, M. Sanden, J. Fagan and R. Primicerio (Food Chemistry 2014, 153: 207–215). Food Chem 2015, 172:921–3.
157. Roza O., Berman L.B.: The pathophysiology of barium: hypokalemic and cardiovascular effects. J Pharmacol Exp Ther 1971, 177(2):433–9.
158. Agarwal A.K. et al.: Hypokalaemic paralysis secondary to acute barium carbonate toxicity. Trop Doct 1995, 25(3):101–3.
159. Armstrong C.M., Taylor S.R.: Interaction of barium ions with potassium channels in squid giant axons. Biophys J 1980, 30(3):473–88.
160. Fosmire G.J.: Zinc toxicity. Am J Clin Nutr 1990, 51(2):225–7.
161. Yakubov E. et al.: Selenium action in neuro-oncology. Biol Trace Elem Res 2014, 161(3):246–54.
162. Chowdhury R. et al.: Association of dietary, circulating, and supplement fatty acids with coronary risk: a systematic review and meta-analysis. Ann Intern Med 2014, 160(6):398–406.
163. Schwingshackl L., Hoffmann G.: Dietary fatty acids in the secondary prevention of coronary heart disease: a systematic review, meta-analysis and meta-regression. BMJ Open 2014, 4(4):e004487.
164. Malatesta M. et al.: A long-term study on female mice fed on a genetically modified soybean: effects on liver ageing. Histochem Cell Biol 2008, 130(5):967–77.
165. Mesfin G.M., Breech K.T.: Heritable nephroblastoma (Wilms’ tumor) in the Upjohn Sprague Dawley rat. Lab Anim Sci 1996, 46(3):321–6.
166. Prejean J.D. et al.: Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 1973, 33(11):2768–73.
167. Nicolia A. et al.: An overview of the last 10 years of genetically engineered crop safety research. Critical reviews in biotechnology 2014, 34(1):77–88.
168. https://www.msu.edu/~howardp./organicindustry.html
169. http://gmopundit.blogspot.ru/2012/09/auchan-and-carrefourfinanced-criigen.html
170. Guyton K.Z. et al.: Carcinogenicity of tetrachlorvinphos, parathion, malathion, diazinon, and glyphosate. Lancet Oncol 2015, 16(5):490–1.
171. DeLoache W.C. et al.: An enzyme-coupled biosensor enables (S) – reticuline production in yeast from glucose. Nat Chem Biol 2015.
172. Shrawat A.K. et al.: Genetic engineering of improved nitrogen use efficiency in rice by the tissue-specific expression of alanine aminotransferase. Plant Biotechnol J 2008, 6(7):722–32.
173. Ермакова И.: Биологические основы гендерных различий. http://eco-irina-ermakovanarodru/art/art4html
174. Hofer T. et al.: New evidence for the theory of the stork. Paediatr Perinat Epidemiol 2004, 18(1):88–92.
175. Cocchi G. et al.: International trends of Down syndrome 1993–2004: Births in relation to maternal age and terminations of pregnancies. Birth Defects Res A Clin Mol Teratol 2010, 88(6):474–9.
176. Snell C. et al.: Assessment of the health impact of GM plant diets in long-term and multigenerational animal feeding trials: a literature review. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2012, 50(3–4):1134–48.
177. Tyshko N.V. et al.: Effect of genetically modified plants on the development of rat progeny. Gig Sanit 2011(6):73–7.
178. Tyshko N.V. et al.: Assessment of the impact of GMO of plant origin on rat progeny development in 3 generations. Vopr Pitan 2011, 80(1):14–28.
179. Doerfler W.: The insertion of foreign DNA into mammalian genomes and its consequences: a concept in oncogenesis. Adv Cancer Res 1995, 66:313–44.
180. Tran N.P. et al.: Control of HPV infection and related cancer through vaccination. Recent Results Cancer Res 2014, 193:149–71.
181. Malatesta M. et al.: Ultrastructural analysis of pancreatic acinar cells from mice fed on genetically modified soybean. J Anat 2002, 201(5):409–15.
182. Malatesta M. et al.: Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean. Eur J Histochem 2005, 49(3):237–42.
183. Sakamoto Y. et al.: A 52-week feeding study of genetically modified soybeans in F344 rats. Shokuhin Eiseigaku Zasshi 2007, 48(3):41–50.
184. Sakamoto Y. et al.: A 104-week feeding study of genetically modified soybeans in F344 rats. Shokuhin Eiseigaku Zasshi 2008, 49(4):272–82.
185. Singh M.B., Bhalla P.L.: Genetic engineering for removing food allergens from plants. Trends Plant Sci 2008, 13(6):257–60.
186. Riascos J.J. et al.: Hypoallergenic legume crops and food allergy: factors affecting feasibility and risk. J Agric Food Chem 2010, 58(1):20–7.
187. Wakasa Y. et al.: Oral immunotherapy with transgenic rice seed containing destructed Japanese cedar pollen allergens, Cry j 1 and Cry j 2, against Japanese cedar pollinosis. Plant Biotechnol J 2013, 11(1):66–76.
188. Takaiwa F., Yang L.: Development of a rice-based peptide vaccine for Japanese cedar and cypress pollen allergies. Transgenic Res 2014, 23(4):573–84.
189. Marshall A.: GM soybeans and health safety – a controversy reexamined. Nat Biotechnol 2007, 25(9):981–7.
190. Zhu Y. et al.: Nutritional assessment and fate of DNA of soybean meal from roundup ready or conventional soybeans using rats. Arch Anim Nutr 2004, 58(4):295–310.
191. Hammond B.G. et al.: The feeding value of soybeans fed to rats, chickens, catfish and dairy cattle is not altered by genetic incorporation of glyphosate tolerance. J Nutr 1996, 126(3):717–27.
192. Brake D.G., Evenson D.P.: A generational study of glyphosate-tolerant soybeans on mouse fetal, postnatal, pubertal and adult testicular development. Food Chem Toxicol 2004, 42(1):29–36.
193. Liener I.E.: The intraperitoneal toxicity of concentrates of the soy bean trypsin inhibitor. J Biol Chem 1951, 193(1):183–91.
194. Gumbmann M.R. et al.: Pancreatic response in rats and mice to trypsin inhibitors from soy and potato after short– and long-term dietary exposure. J Nutr 1989, 119(11):1598–609.
195. European Comission: A decade of EU-funded GMO
research. http://eceuropaeu/research/biosociety/pdf/a_decade_of_eu-funded_gmo_researchpdf 2010
196. Shaw K. et al.: Tryptophan and 5-hydroxytryptophan for depression. Cochrane Database Syst Rev 2002(1):CD003198.
197. Slutsker L. et al.: Eosinophilia-myalgia syndrome associated with exposure to tryptophan from a single manufacturer. JAMA 1990, 264(2):213–7.
198. Scientific Opinion on the safety and efficacy of L-tryptophan produced by Escherichia coli CGMCC 7.59 for all animal species based on a dossier submitted by HELM AG on behalf of Meihua Holdings Co. Ltd. EFSA Journal 2015, 13(2):4015.
199. Savely V.R. et al.: The mystery of Morgellons disease: infection or delusion? Am J Clin Dermatol 2006, 7(1):1–5.
200. Pearson M.L. et al.: Clinical, epidemiologic, histopathologic and molecular features of an unexplained dermopathy. PLOS ONE 2012, 7(1):e29908.
201. Middelveen M.J. et al.: Characterization and evolution of dermal filaments from patients with Morgellons disease. Clin Cosmet Investig Dermatol 2013, 6:1–21.
202. Gruzza M. et al.: Gene transfer from engineered Lactococcus lactis strains to Enterococcus faecalis in the digestive tract of gnotobiotic mice. Microb Releases 1993, 2(3):121–5.
203. Netherwood T. et al.: Gene transfer in the gastrointestinal tract. Appl Environ Microbiol 1999, 65(11):5139–41.
204. Schubbert R. et al.: Ingested foreign (phage M13) DNA survives transiently in the gastrointestinal tract and enters the bloodstream of mice. Mol Gen Genet 1994, 242(5):495–504.
205. Schubbert R. et al.: Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA. Proc Natl Acad Sci U S A 1997, 94(3):961–6.
206. Schubbert R. et al.: On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission to the fetus. Mol Gen Genet 1998, 259(6):569–76.
207. Hohlweg U., Doerfler W.: On the fate of plant or other foreign genes upon the uptake in food or after intramuscular injection in mice. Mol Genet Genomics 2001, 265(2): 225–33.
208. Panchin A.Y. et al.: Human trash ESTs – sequences from cDNA collection that are not aligned to genome assembly. J Bioinform Comput Biol 2008, 6(4):759–73.
209. Folmer J.D. et al.: Utilization of Bt corn residues by grazing beef steers and Bt corn silage and grain by growing beef cattle and lactating dairy cows. J Anim Sci 2002, 80(5):1352–61.
210. Llorente B. et al.: Improvement of aroma in transgenic potato as a consequence of impairing tuber browning. PLOS ONE 2010, 5(11):e14030.
211. Davidovich-Rikanati R. et al.: Enrichment of tomato flavor by diversion of the early plastidial terpenoid pathway. Nat Biotechnol 2007, 25(8):899–901.
212. Jian L. et al.: Tea and lycopene protect against prostate cancer.Asia Pac J Clin Nutr 2007, 16 Suppl 1:453–7.
213. http://www.youtube.com/watch?v=QzS0DX0Vx8Y
214. Gill S.S. et al.: The mode of action of Bacillus thuringiensis endotoxins. Annual Rev Entomol 1992, 37:615–36.
215. Losey J.E. et al.: Transgenic pollen harms monarch larvae. Nature 1999, 399(6733):214.
216. Sears M.K. et al.: Impact of Bt corn pollen on monarch butterfly populations: a risk assessment. Proc Natl Acad Sci USA 2001, 98(21):11937–42.
217. Gatehouse A.M. et al.: The case of the monarch butterfly: a verdict is returned. Trends Genet 2002, 18(5):249–51.
218. Rosi-Marshall E.J. et al.: Toxins in transgenic crop byproducts may affect headwater stream ecosystems. Proc Natl Acad Sci USA 2007, 104(41):16204–8.
219. Chambers C.P. et al.: Responses of stream macroinvertebrates to Bt maize leaf detritus. Ecol Appl 2010, 20(7):1949–60.
220. Guo Y. et al.: The Cultivation of Bt Corn Producing Cry1Ac Toxins Does Not Adversely Affect Non-Target Arthropods. PLOS ONE 2014, 9(12):e114228.
221. Duan J.J. et al.: A meta-analysis of effects of Bt crops on honey bees (Hymenoptera: Apidae). PLOS ONE 2008, 3(1):e1415.
222. Lemaux P.G.: Genetically engineered plants and foods: a scientist’s analysis of the issues (part II). Annual Rev Plant Biol 2009, 60:511–59.
223. Gill R.J. et al.: Combined pesticide exposure severely affects individual– and colony-level traits in bees. Nature 2012, 491(7422):105–8.
224. Carpenter J.E.: Peer-reviewed surveys indicate positive impact of commercialized GM crops. Nat Biotechnol 2010, 28(4):319–21.
225. GruÈre G. et al.: Bt Cotton and Farmer Suicides in India: Reviewing the Evidence. IFPRI Discussion Paper 00808 2008.
226. Sheridan C.: Doubts surround link between Bt cotton failure and farmer suicide. Nat Biotechnol 2009, 27(1):9–10.
227. Kathage J., Qaim M.: Economic impacts and impact dynamics of Bt (Bacillus thuringiensis) cotton in India. Proc Natl Acad Sci USA 2012, 109(29):11652–6.
228. Bradberry S.M. et al.: Glyphosate poisoning. Toxicol Rev 2004, 23(3):159–67.
229. Sribanditmongkol P. et al.: Pathological and toxicological findings in glyphosate-surfactant herbicide fatality: a case report. Am J Forensic Med Pathol 2012, 33(3):234–7.
230. Schinasi L., Leon M.E.: Non-Hodgkin lymphoma and occupational exposure to agricultural pesticide chemical groups and active ingredients: a systematic review and meta-analysis. Int J Environ Res Public Health 2014, 11(4):4449–527.
231. Mink P.J. et al.: Epidemiologic studies of glyphosate and cancer: a review. Regul Toxicol Pharmacol 2012, 63(3):440–52.
232. Mink P.J. et al.: Epidemiologic studies of glyphosate and noncancer health outcomes: a review. Regul Toxicol Pharmacol 2011, 61(2):172–84.
233. Williams A.L. et al.: Developmental and reproductive outcomes in humans and animals after glyphosate exposure: a critical analysis. J Toxicol Environ Health B Crit Rev 2012, 15(1):39–96.
234. Aris A., Leblanc S.: Maternal and fetal exposure to pesticides associated to genetically modified foods in Eastern Townships of Quebec, Canada. Reprod Toxicol 2011, 31(4):528–33.
235. Paul V. et al.: Development and validation of a sensitive enzyme immunoassay for surveillance of Cry1Ab toxin in bovine blood plasma of cows fed Bt-maize (MON810). Anal Chim Acta 2008, 607(1):106–13.
236. Kwit C. et al.: Transgene introgression in crop relatives: molecular evidence and mitigation strategies. Trends Biotechnol 2011, 29(6):284–93.
237. http://www.gmofreeusa.org/enigma-portfolio/gmo-science-2/
238. Srivastava V. et al.: Single-copy transgenic wheat generated through the resolution of complex integration patterns. Proc Natl Acad Sci USA 1999, 96(20):11117–21.
239. Bakke-McKellep A. M. et al.: Histological, digestive, metabolic, hormonal and some immune factor responses in Atlantic salmon, Salmo salar L., fed genetically modified soybeans. J Fish Dis 2007, 30(2):65–79.
240. http://www.trinitas.ru/rus/doc/0016/001c/00161613.htm
241. https://isaaa.org/gmapprovaldatabase/countrylist/default.asp
242. Key S. et al.: Genetically modified plants and human health. J R Soc Med 2008, 101(6):290–8.
243. Cascini F.: Investigations into the hypothesis of transgenic cannabis. J Forensic Sci 2012, 57(3):718–21.
244. Abecasis G.R. et al.: A map of human genome variation from population-scale sequencing. Nature 2010, 467(7319): 1061–73.
245. Weigel D., Mott R.: The 1001 genomes project for Arabidopsis thaliana. Genome Biol 2009, 10(5):107.
246. The 3,000 rice genomes project. Gigascience 2014, 3:7.
247. Holst-Jensen A. et al.: PCR technology for screening and quantification of genetically modified organisms (GMOs). Anal Bioanal Chem 2003, 375(8):985–93.
248. Mullis K. et al.: Specific enzymatic amplification of DNA in vitro: the polymerase chain reaction. Cold Spring Harb Symp Quant Biol 1986, 51 Pt 1:263–73.
249. Clelland C.T. et al.: Hiding messages in DNA microdots. Nature 1999, 399(6736):533–4.
250. Munns R. et al.: Wheat grain yield on saline soils is improved by an ancestral Na(+) transporter gene. Nat Biotechnol 2012, 30(4):360–4.
251. Chen D. et al.: HIF-1 modulates dietary restriction-mediated lifespan extension via IRE-1 in Caenorhabditis elegans. PLoS Genet 2009, 5(5):e1000486.
252. Jouanin L. et al.: Lignification in transgenic poplars with extremely reduced caffeic acid O-methyltransferase activity. Plant Physiol 2000, 123(4):1363–74.
253. Sheehy R.E. et al.: Reduction of polygalacturonase activity in tomato fruit by antisense RNA. Proc Natl Acad Sci USA 1988, 85(23):8805–9.
254. Tuteja J.H. et al.: Tissue-specific gene silencing mediated by a naturally occurring chalcone synthase gene cluster in Glycine max. Plant Cell 2004, 16(4):819–35.
255. Todd J.J., Vodkin L.O.: Duplications That Suppress and Deletions That Restore Expression from a Chalcone Synthase Multigene Family. Plant Cell 1996, 8(4):687–99.
256. Parrott W. et al.: Application of food and feed safety assessment principles to evaluate transgenic approaches to gene modulation in crops. Food Chem Toxicol 2010, 48(7):1773–90.
257. Denis M. et al.: Expression of Engineered Nuclear Male Sterility in Brassica napus (Genetics, Morphology, Cytology, and Sensitivity to Temperature). Plant Physiol 1993, 101(4):1295–304.
258. Granzier H.L., Labeit S.: The giant muscle protein titin is an adjustable molecular spring. Exerc Sport Sci Rev 2006, 34(2):50–3.
259. Bang M.L. et al.: The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circ Res 2001, 89(11):1065–72.
260. Neves G. et al.: Stochastic yet biased expression of multiple Dscam splice variants by individual cells. Nat Genet 2004, 36(3):240–6.
261. Hattori D. et al.: Dscam-mediated cell recognition regulates neural circuit formation. Annu Rev Cell Dev Biol 2008, 24:597–620.
262. Noren C.J. et al.: Dissecting the Chemistry of Protein Splicing and Its Applications. Angew Chem Int Ed Engl 2000, 39(3):450–66.
263. Holley R.W. et al.: Nucleotide Sequences in the Yeast Alanine Transfer Ribonucleic Acid. J Biol Chem 1965, 240:2122–8.
264. Min Jou W. et al.: Nucleotide sequence of the gene coding for the bacteriophage MS2 coat protein. Nature 1972, 237(5350):82–8.
265. Maxam A.M., Gilbert W.: A new method for sequencing DNA. Proc Natl Acad Sci USA 1977, 74(2):560–4.
266. Sanger F. et al.: DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 1977, 74(12):5463–7.
267. Smith L.M. et al.: Fluorescence detection in automated DNA sequence analysis. Nature 1986, 321(6071):674–9.
268. Fleischmann R.D. et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 1995, 269(5223):496–512.
269. Genome sequence of the nematode C. elegans: a platform for investigating biology. Science 1998, 282(5396):2012–8.
270. Analysis of the genome sequence of the flowering plant Arabidopsis thaliana. Nature 2000, 408(6814):796–815.
271. Staden R.: A strategy of DNA sequencing employing computer programs. Nucleic Acids Res 1979, 6(7):2601–10.
272. Adams M.D. et al.: The genome sequence of Drosophila melanogaster. Science 2000, 287(5461):2185–95.
273. Venter J.C. et al.: The sequence of the human genome. Science 2001, 291(5507):1304–51.
274. Lander E.S. et al.: Initial sequencing and analysis of the human genome. Nature 2001, 409(6822):860–921.
275. Initial sequence of the chimpanzee genome and comparison with the human genome. Nature 2005, 437(7055):69–87.
276. Yunis J.J., Prakash O.: The origin of man: a chromosomal pictorial legacy. Science 1982, 215(4539):1525–30.
277. Fan Y. et al.: Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes. Genome Res 2002, 12(11):1651–62.
278. Eid J. et al.: Real-time DNA sequencing from single polymerase molecules. Science 2009, 323(5910):133–8.
279. Mikheyev A.S., Tin M.M.: A first look at the Oxford Nanopore MinION sequencer. Mol Ecol Resour 2014, 14(6):1097–102.
280. Chan I.S., Ginsburg G.S.: Personalized medicine: progress and promise. Annu Rev Genomics Hum Genet 2011, 12:217–44.
281. El-Sohemy A. et al.: Coffee, CYP1A2 genotype and risk of myocardial infarction. Genes Nutr 2007, 2(1):155–6.
282. Muramatsu T. et al.: Alcohol and aldehyde dehydrogenase geno types and drinking behavior of Chinese living in Shanghai. Hum Genet 1995, 96(2):151–4.
283. Bierut L.J. et al.: ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry 2012, 17(4):445–50.
284. Venter J.C. et al.: Environmental genome shotgun sequencing of the Sargasso Sea. Science 2004, 304(5667):66–74.
285. Turnbaugh P.J. et al.: The human microbiome project. Nature 2007, 449(7164):804–10.
286. Arumugam M. et al.: Enterotypes of the human gut microbiome. Nature 2011, 473(7346):174–80.
287. Lamendella R. et al.: Comparative fecal metagenomics unveils unique functional capacity of the swine gut. BMC Microbiol 2011, 11:103.
288. Tazume S. et al.: Effects of germfree status and food restriction on longevity and growth of mice. Jikken Dobutsu 1991, 40(4):517–22.
289. Oresic M. et al.: Gut microbiota affects lens and retinal lipid composition. Exp Eye Res 2009, 89(5):604–7.
290. Ridaura V.K. et al.: Gut microbiota from twins discordant for obesity modulate metabolism in mice. Science 2013, 341(6150):1241214.
291. Vasquez A. et al.: Vaginal lactobacillus flora of healthy Swedish women. J Clin Microbiol 2002, 40(8):2746–9.
292. Tuzhikov A. et al.: TUIT, a BLAST-based tool for taxonomic classification of nucleotide sequences. Biotechniques 2014, 56(2):78–84.
293. Bercik P. et al.: Microbes and the gut-brain axis. Neurogastroenterol Motil 2012, 24(5):405–13.
294. Foster J.A., McVey Neufeld K.A.: Gut-brain axis: how the microbiome influences anxiety and depression. Trends Neurosci 2013, 36(5):305–12.
295. Cryan J.F., Dinan T.G.: Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nat Rev Neurosci 2012, 13(10):701–12.
296. Panchin A.Y. et al.: Midichlorians – the biomeme hypothesis: is there a microbial component to religious rituals? Biol Direct 2014, 9:14.
297. Brenner S.R.: Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in horses. Med Hypotheses 2013, 80(1):103.
298. Bhattacharjee S., Lukiw W.J.: Alzheimer’s disease and the microbiome. Front Cell Neurosci 2013, 7:153.
299. Hirakawa H. et al.: Dissection of the octoploid strawberry genome by deep sequencing of the genomes of Fragaria species. DNA Res 2014, 21(2):169–81.
300. Shimomura O. et al.: Extraction, purification and properties of aequorin, a bioluminescent protein from the luminous hydromedusan, Aequorea. J Cell Comp Physiol 1962, 59:223–39.
301. Prasher D.C. et al.: Primary structure of the Aequorea victoria green-fluorescent protein. Gene 1992, 111(2):229–33.
302. Chalfie M. et al.: Green fluorescent protein as a marker for gene expression. Science 1994, 263(5148):802–5.
303. Heim R. et al.: Improved green fluorescence. Nature 1995, 373(6516):663–4.
304. Matz M.V. et al.: Fluorescent proteins from nonbioluminescent Anthozoa species. Nat Biotechnol 1999, 17(10):969–73.
305. Terskikh A. et al.: “Fluorescent timer”: protein that changes color with time. Science 2000, 290(5496):1585–8.
306. Livet J. et al.: Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature 2007, 450(7166):56–62.
307. Klein R.M. et al.: High-velocity microprojectiles for delivering nucleic acids into living cells. 1987. Biotechnology 1992, 24:384–6.
308. Daniell H. et al.: Transient foreign gene expression in chloroplasts of cultured tobacco cells after biolistic delivery of chloroplast vectors. Proc Natl Acad Sci USA 1990, 87(1):88–92.
309. Zambryski P. et al.: Ti plasmid vector for the introduction of DNA into plant cells without alteration of their normal regeneration capacity. EMBO J 1983, 2(12):2143–50.
310. Mojica F.J. et al.: Biological significance of a family of regularly spaced repeats in the genomes of Archaea, Bacteria and mitochondria. Mol Microbiol 2000, 36(1):244–6.
311. Pourcel C. et al.: CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies. Microbiology 2005, 151(Pt 3):653–63.
312. Mojica F.J. et al.: Intervening sequences of regularly spaced prokaryotic repeats derive from foreign genetic elements. J Mol Evol 2005, 60(2):174–82.
313. Bolotin A. et al.: Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin. Microbiology 2005, 151(Pt 8):2551–61.
314. Makarova K.S. et al.: A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Biol Direct 2006, 1:7.
315. Barrangou R. et al.: CRISPR provides acquired resistance against viruses in prokaryotes. Science 2007, 315(5819):1709–12.
316. Jinek M. et al.: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science 2012, 337(6096):816–21.
317. Jinek M. et al.: RNA-programmed genome editing in human cells. Elife 2013, 2:e00471.
318. Wang H. et al.: One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering. Cell 2013, 153(4):910–8.
319. Gantz V.M., Bier E.: Genome editing. The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations. Science 2015, 348(6233):442–4.
320. Liang P. et al.: CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell 2015, 6(5):363–72.
321. Ran F.A. et al.: Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell 2013, 154(6):1380–9.
322. Tsai S.Q. et al.: Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol 2014, 32(6):569–76.
323. Guilinger J.P. et al.: Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol 2014, 32(6):577–82.
324. Davis K.M. et al.: Small molecule-triggered Cas9 protein with improved genome-editing specificity. Nat Chem Biol 2015, 11(5):316–8.
325. Maruyama T. et al.: Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining. Nat Biotechnol 2015, 33(5):538–42.
326. Chu V.T. et al.: Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. Nat Biotechnol 2015, 33(5):543–8.
327. Hemphill J. et al.: Optical Control of CRISPR/Cas9 Gene Editing. J Am Chem Soc 2015, 137(17):5642–5.
328. Nihongaki Y. et al.: Photoactivatable CRISPR-Cas9 for optogenetic genome editing. Nat Biotechnol 2015.
329. Chapman K.M. et al.: Targeted Germline Modifications in Rats Using CRISPR/Cas9 and Spermatogonial Stem Cells. Cell Rep 2015, 10(11):1828–35.
330. Gibson D.G. et al.: Creation of a bacterial cell controlled by a chemically synthesized genome. Science 2010, 329(5987):52–6.
331. Howard T.P. et al.: Synthesis of customized petroleum-replica fuel molecules by targeted modification of free fatty acid pools in Escherichia coli. Proc Natl Acad Sci USA 2013, 110(19):7636–41.
332. Sarria S. et al.: Microbial synthesis of pinene. ACS Synth Biol 2014, 3(7):466–75.
333. Kolisnychenko V. et al.: Engineering a reduced Escherichia coli genome. Genome Res 2002, 12(4):640–7.
334. Posfai G. et al.: Emergent properties of reduced-genome Escherichia coli. Science 2006, 312(5776):1044–6.
335. Malyshev D.A. et al.: A semi-synthetic organism with an expanded genetic alphabet. Nature 2014, 509(7500):385–8.
336. Kim T. et al.: A Synthetic Erectile Optogenetic Stimulator Enabling Blue-Light-Inducible Penile Erection. Angew Chem Int Ed Engl 2015.
337. Ferreira A. et al.: Sickle hemoglobin confers tolerance to Plasmodium infection. Cell 2011, 145(3):398–409.
338. Gao Z. et al.: An estimate of the average number of recessive lethal mutations carried by humans. Genetics 2015, 199(4):1243–54.
339. Novotna M. et al.: Toxoplasma and reaction time: role of toxoplasmosis in the origin, preservation and geographical distribution of Rh blood group polymorphism. Parasitology 2008, 135(11): 1253–61.
340. Pappas G. et al.: Toxoplasmosis snapshots: global status of Toxoplasma gondii seroprevalence and implications for pregnancy and congenital toxoplasmosis. Int J Parasitol 2009, 39(12):1385–94.
341. Flegr J. et al.: Increased incidence of traffic accidents in Toxoplasma-infected military drivers and protective effect RhD molecule revealed by a large-scale prospective cohort study. BMC Infect Dis 2009, 9:72.
342. Hart R., Norman R.J.: The longer-term health outcomes for children born as a result of IVF treatment: Part I – General health outcomes. Hum Reprod Update 2013, 19(3):232–43.
343. Hart R., Norman R.J.: The longer-term health outcomes for children born as a result of IVF treatment. Part II – Mental health and development outcomes. Hum Reprod Update 2013, 19(3):244–50.
344. Brinton L.A. et al.: In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services. Fertil Steril 2013, 99(5):1189–96.
345. Reigstad M.M. et al.: Risk of breast cancer following fertili ty treatment – a registry based cohort study of parous women in Norway. Int J Cancer 2015, 136(5):1140–8.
346. Fan H.C. et al.: Noninvasive diagnosis of fetal aneuploidy by shotgun sequencing DNA from maternal blood. Proc Natl Acad Science USA 2008, 105(42):16266–71.
347. Schneider A. et al.: Population-based Tay-Sachs screening among Ashkenazi Jewish young adults in the 21st century: Hexosaminidase A enzyme assay is essential for accurate testing. Am J Med Genet A 2009, 149A(11):2444–7.
348. Cao A. et al.: Control of beta-thalassaemia by carrier screening, genetic counselling and prenatal diagnosis: the Sardinian experience. Ciba Found Symp 1996, 197:137–51; discussion 51–5.
349. White G. et al.: Clinical evaluation of recombinant factor IX. Semin Hematol 1998, 35(2 Suppl 2):33–8.
350. Sands M.S.: AAV-mediated liver-directed gene therapy. Methods Mol Biol 2011, 807:141–57.
351. Nathwani A.C. et al.: Long-term safety and efficacy of factor IX gene therapy in hemophilia B. N Engl J Med 2014, 371(21):1994–2004.
352. Cavazzana-Calvo M. et al.: Gene therapy of human severe combined immunodeficiency (SCID) – X1 disease. Science 2000, 288(5466):669–72.
353. Hacein-Bey-Abina S. et al.: A modified gamma-retrovirus vector for X-linked severe combined immunodeficiency. N Engl J Med 2014, 371(15):1407–17.
354. Ivics Z. et al.: Molecular reconstruction of Sleeping Beauty, a Tc1-like transposon from fish, and its transposition in human cells. Cell 1997, 91(4):501–10.
355. Collier L.S., Largaespada D.A.: Transposons for cancer gene discovery: Sleeping Beauty and beyond. Genome Biol 2007, 8 Suppl 1:S15.
356. Aronovich E.L. et al.: The Sleeping Beauty transposon system: a non-viral vector for gene therapy. Hum Mol Genet 2011, 20(R1):R14–20.
357. Schmitt T.M. et al.: T cell receptor gene therapy for cancer. Hum Gene Ther 2009, 20(11):1240–8.
358. Clay T.M. et al.: Efficient transfer of a tumor antigen-reactive TCR to human peripheral blood lymphocytes confers anti-tumor reactivity. J Immunol 1999, 163(1):507–13.
359. Roth J.A. et al.: p53 tumor suppressor gene therapy for cancer. Oncology (Williston Park) 1999, 13(10 Suppl 5):148–54.
360. Chen G.X. et al.: Clinical utility of recombinant adenoviral human p53 gene therapy: current perspectives. Onco Targets Ther 2014, 7:1901–9.
361. Collin S.P., Trezise A.E.: The origins of colour vision in vertebrates. Clin Exp Optom 2004, 87(4–5):217–23.
362. Jacobs G.H.: Evolution of colour vision in mammals. Philos Trans R Soc Lond B Biol Sci 2009, 364(1531):2957–67.
363. Panchin A.Y. et al.: Asymmetric and non-uniform evolution of recently duplicated human genes. Biol Direct 2010, 5:54.
364. Yokoyama S. et al.: Molecular basis of spectral tuning in the redand green-sensitive (M/LWS) pigments in vertebrates. Genetics 2008, 179(4):2037–43.
365. Deeb S. et al.: Structure-function relationships in human red/green color vision. Documenta Ophthalmologica Proceedings Series 1993, 56:13–7.
366. Jordan G. et al.: The dimensionality of color vision in carriers of anomalous trichromacy. J Vis 2010, 10(8):12.
367. Mancuso K. et al.: Gene therapy for red-green colour blindness in adult primates. Nature 2009, 461(7265):784–7.
368. Simonelli F. et al.: Gene therapy for Leber’s congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther 2010, 18(3):643–50.
369. Tomita H. et al.: Channelrhodopsin-2 gene transduced into retinal ganglion cells restores functional vision in genetically blind rats. Exp Eye Res 2010, 90(3):429–36.
370. Ramirez S. et al.: Creating a false memory in the hippocampus. Science 2013, 341(6144):387–91.
371. Bruegmann T. et al.: Optogenetic control of contractile function in skeletal muscle. Nat Commun 2015, 6:7153.
372. Samson M. et al.: Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 1996, 382(6593):722–5.
373. Dean M. et al.: Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science 1996, 273(5283):1856–62.
374. Hutter G. et al.: Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med 2009, 360(7):692–8.
375. Allers K. et al.: Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood 2011, 117(10):2791–9.
376. Tebas P. et al.: Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med 2014, 370(10):901–10.
377. Ebina H. et al.: Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus. Sci Rep 2013, 3:2510.
378. O’Connell M.R. et al.: Programmable RNA recognition and cleavage by CRISPR/Cas9. Nature 2014, 516(7530):263–6.
379. Foster H. et al.: Genetic therapeutic approaches for Duchenne muscular dystrophy. Hum Gene Ther 2012, 23(7):676–87.
380. Yamamoto H. et al.: NCoR1 is a conserved physiological modulator of muscle mass and oxidative function. Cell 2011, 147(4):827–39.
381. Hedrick P.W.: Virgin birth, genetic variation and inbreeding. Biol Lett 2007, 3(6):715–6.
382. Davis G.K: Cyclical parthenogenesis and viviparity in aphids as evolutionary novelties. J Exp Zool B Mol Dev Evol 2012, 318(6):448–59.
383. Bulletti C. et al.: The artificial womb. Ann NY Acad Sci 2011, 1221:124–8.
384. Devlin B. et al.: The heritability of IQ. Nature 1997, 388(6641): 468–71.
385. Plomin R. et al.: Variability and stability in cognitive abilities are largely genetic later in life. Behav Genet 1994, 24(3):207–15.
386. Spitz E. et al.: Comparative diagnoses of twin zygosity by SSLP variant analysis, questionnaire, and dermatoglyphic analysis. Behav Genet 1996, 26(1):55–63.
387. Karaismailoglu S., Erdem A.: The effects of prenatal sex steroid hormones on sexual differentiation of the brain. J Turk Ger Gynecol Assoc 2013, 14(3):163–7.
388. Zhang S. et al.: Serotonin signaling in the brain of adult female mice is required for sexual preference. Proc Natl Acad Sci USA 2013, 110(24):9968–73.
389. Rogaev E.I. et al.: Genotype analysis identifies the cause of the “royal disease”. Science 2009, 326(5954):817.
390. Miller W. et al.: Sequencing the nuclear genome of the extinct woolly mammoth. Nature 2008, 456(7220):387–90.
391. Baker A.J. et al.: Genomic support for a moa-tinamou clade and adaptive morphological convergence in flightless ratites. Mol Biol Evol 2014, 31(7):1686–96.
392. Prufer K. et al.: The complete genome sequence of a Neanderthal from the Altai Mountains. Nature 2014, 505(7481):43–9.
393. Lynch V. et al.: Elephantid genomes reveal the molecular bases of Woolly Mammoth adaptations to the arctic. BioRxiv 2015.
394. Chesne P. et al.: Cloned rabbits produced by nuclear transfer from adult somatic cells. Nat Biotechnol 2002, 20(4):366–9.
395. Campbell K.H. et al.: Sheep cloned by nuclear transfer from a cultured cell line. Nature 1996, 380(6569):64–6.
396. Чайлахян Л. et al.: Электростимулируемое слияние клеток в клеточной инженерии. Биофизика 1987, 32(5):874–87.
397. Meng L. et al.: Rhesus monkeys produced by nuclear transfer. Biol Reprod 1997, 57(2):454–9.
398. Cozzi J. et al.: Procedures for somatic cell nuclear transfer in the rat. Methods Mol Biol 2010, 597:137–50.
399. Wakayama S. et al.: Production of cloned mice from somatic cells, ES cells, and frozen bodies. Methods Enzymol 2010, 476:151–69.
400. Arat S. et al.: 22 semen and reproductive profiles of cloned anatolian grey cattle. Reprod Fertil Dev 2014, 27(1):103–4.
401. Woods G.L et al.: A mule cloned from fetal cells by nuclear transfer. Science 2003, 301(5636):1063.
402. Galli C. et al.: Somatic cell nuclear transfer in horses. Reprod Domest Anim 2008, 43 Suppl 2:331–7.
403. Shin T. et al.: A cat cloned by nuclear transplantation. Nature 2002, 415(6874):859.
404. Lee B.C. et al.: Dogs cloned from adult somatic cells. Nature 2005, 436(7051):641.
405. Loi P. et al.: Genetic rescue of an endangered mammal by crossspecies nuclear transfer using post-mortem somatic cells. Nat Biotechnol 2001, 19(10):962–4.
406. Vanderwall D.K. et al.: Equine cloning: applications and
outcomes. Reprod Fertil Dev 2006, 18(1–2):91–8.
407. Wakayama S. et al.: Successful serial recloning in the mouse over multiple generations. Cell Stem Cell 2013, 12(3):293–7.
408. French A.J. et al.: Development of human cloned blastocysts following somatic cell nuclear transfer with adult fibroblasts. Stem Cells 2008, 26(2):485–93.
409. Unno N. et al.: Development of an artificial placenta: survival of isolated goat fetuses for three weeks with umbilical arteriovenous extracorporeal membrane oxygenation. Artif Organs 1993, 17(12):996–1003.
410. Kfoury C.: Therapeutic cloning: promises and issues. Mcgill J Med 2007, 10(2):112–20.
411. Nayernia K. et al.: In vitro-differentiated embryonic stem cells give rise to male gametes that can generate offspring mice. Dev Cell 2006, 11(1):125–32.
412. Easley C.A. et al.: Gamete derivation from embryonic stem cells, induced pluripotent stem cells or somatic cell nuclear transfer-derived embryonic stem cells: state of the art. Reprod Fertil Dev 2014, 27(1):89–92.
413. Denton P.W., Garcia J.V.: Novel humanized murine models for HIV research. Curr HIV/AIDS Rep 2009, 6(1):13–9.
414. Espuny-Camacho I. et al.: Pyramidal neurons derived from human pluripotent stem cells integrate efficiently into mouse brain circuits in vivo. Neuron 2013, 77(3):440–56.
415. Strom S.C. et al.: Chimeric mice with humanized liver: tools for the study of drug metabolism, excretion, and toxicity. Methods Mol Biol 2010, 640:491–509.
416. Han X. et al.: Forebrain engraftment by human glial progenitor cells enhances synaptic plasticity and learning in adult mice. Cell Stem Cell 2013, 12(3):342–53.
417. Schwitzgebel E.: Do ethicists steal more books? Philosophical Psychology 2009, 22(6):711–25.
418. Olovnikov A.M.: Telomeres, telomerase, and aging: origin of the theory. Exp Gerontol 1996, 31(4):443–8.
419. Betts D. et al.: Reprogramming of telomerase activity and rebuilding of telomere length in cloned cattle. Proc Natl Acad Sci USA 2001, 98(3):1077–82.
420. Poss K.D. et al.: Heart regeneration in zebrafish. Science 2002, 298(5601):2188–90.
421. Engel F.B. et al.: FGF1/p38 MAP kinase inhibitor therapy induces cardiomyocyte mitosis, reduces scarring, and rescues function after myocardial infarction. Proc Natl Acad Sci USA 2006, 103(42):15546–51.
422. Bedelbaeva K. et al.: Lack of p21 expression links cell cycle control and appendage regeneration in mice. Proc Natl Acad Sci USA 2010, 107(13):5845–50.
423. Murphy S.V., Atala A.: 3D bioprinting of tissues and organs. Nat Biotechnol 2014, 32(8):773–85.
424. Ventola C.L.: Medical Applications for 3D Printing: Current and Projected Uses. P T 2014, 39(10):704–11.
425. Buffenstein R.: Negligible senescence in the longest living rodent, the naked mole-rat: insights from a successfully aging species. J Comp Physiol B 2008, 178(4):439–45.
426. Kim E.B. et al.: Genome sequencing reveals insights into physiology and longevity of the naked mole rat. Nature 2011, 479(7372):223–7.
427. Seluanov A. et al.: Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat. Proc Natl Acad Sci USA 2009, 106(46):19352–7.
428. McCay C.M. et al.: The effect of retarded growth upon the length of life span and upon the ultimate body size. 1935. Nutrition 1989, 5(3):155–71; discussion 72.
429. Szafranski K., Mekhail K.: The fine line between lifespan extension and shortening in response to caloric restriction. Nucleus 2014, 5(1):56–65.
430. Mattison J.A. et al.: Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature 2012, 489(7415):318–21.
431. Carey J.R. et al.: Life history response of Mediterranean fruit flies to dietary restriction. Aging cell 2002, 1(2):140–8.
432. Kasumovic M.M. et al.: Body condition but not dietary restriction prolongs lifespan in a semelparous capital breeder. Biology letters 2009, 5(5):636–8.
433. Cooper T.M. et al.: Effect of caloric restriction on life span of the housefly, Musca domestica. FASEB journal: official publication of the Federation of American Societies for Experimental Biology 2004, 18(13):1591–3.
434. Cava E., Fontana L.: Will calorie restriction work in humans? Aging (Albany NY) 2013, 5(7):507–14.
435. Madeo F. et al.: Can autophagy promote longevity? Nature cell biology 2010, 12(9):842–6.
436. Eisenberg T. et al.: Induction of autophagy by spermidine promotes longevity. Nature cell biology 2009, 11(11):1305–14.
437. Morselli E. et al.: Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell death & disease 2010, 1:e10.
438. Hansen M. et al.: A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS genetics 2008, 4(2):e24.
439. Jia K., Levine B.: Autophagy is required for dietary restriction-mediated life span extension in C. elegans. Autophagy 2007, 3(6):597–9.
440. Lum J.J. et al.: Autophagy in metazoans: cell survival in the land of plenty. Nature reviews Molecular cell biology 2005, 6(6):439–48.
441. Ravikumar B. et al.: Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nature genetics 2004, 36(6):585–95.
442. Beauchamp E.M., Platanias L.C.: The evolution of the TOR pathway and its role in cancer. Oncogene 2013, 32(34):3923–32.
443. Saiki S. et al.: Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition. Autophagy 2011, 7(2):176–87.
444. Zhou H. et al.: Updates of mTOR inhibitors. Anti-cancer agents in medicinal chemistry 2010, 10(7):571–81.
445. Dowling R.J. et al.: Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Res 2007, 67(22):10804–12.
446. Chin R.M. et al.: The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 2014.
447. Leontieva O.V. et al.: Weekly administration of rapamycin improves survival and biomarkers in obese male mice on high-fat diet. Aging cell 2014.
448. Fok W.C. et al.: Mice fed rapamycin have an increase in life span associated with major changes in the liver transcriptome. PLOS ONE 2014, 9(1):e83988.
449. Miller R.A. et al.: Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction. Aging Cell 2014, 13(3):468–77.
450. Harrison D.E. et al.: Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460(7253):392–5.
451. Baur J.A. et al.: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006, 444(7117):337–42.
452. Miller R.A. et al.: Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. The journals of gerontology Series A, Biological sciences and medical sciences 2011, 66(2):191–201.
453. Elmadhun N.Y. et al.: Alcohol Consumption Mitigates Apoptosis and Mammalian Target of Rapamycin Signaling in Myocardium. Journal of the American College of Surgeons 2014.
454. Foster D.A.: Reduced mortality and moderate alcohol consumption: the phospholipase D-mTOR connection. Cell cycle 2010, 9(7):1291–4.
455. Yu X. et al.: Beneficial and harmful effects of alcohol exposure on Caenorhabditis elegans worms. Biochemical and biophysical research communications 2011, 412(4):757–62.
456. Correia S. et al.: Mechanisms of action of metformin in type 2 diabetes and associated complications: an overview. Mini Rev Med Chem 2008, 8(13):1343–54.
457. Onken B., Driscoll M.: Metformin induces a dietary restriction-like state and the oxidative stress response to extend C. elegans Healthspan via AMPK, LKB1, and SKN-1. PLOS ONE 2010, 5(1):e8758.
458. Martin-Montalvo A. et al.: Metformin improves healthspan and lifespan in mice. Nat Commun 2013, 4:2192.
459. Chin R.M. et al.: The metabolite alpha-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR. Nature 2014, 510(7505):397–401.
460. Bhattacharya R. et al.: Toxicity of alpha-ketoglutarate following 14-days repeated oral administration in Wistar rats. Cellular and molecular biology 2011, 57 Suppl: OL1543–9.
461. Bhattacharya R., Vijayaraghavan R.: Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide. Human & experimental toxicology 2002, 21(6):297–303.
462. Bhattacharya R. et al.: Biochemical, oxidative and histological changes caused by sub-acute oral exposure of some synthetic cyanogens in rats: Ameliorative effect of alpha-ketoglutarate. Food and chemical toxicology: an international journal published for the British Industrial Biological Research Association 2014, 67:201–11.
463. Hariharakrishnan J. et al.: Cyanide-induced changes in the levels of neurotransmitters in discrete brain regions of rats and their response to oral treatment with alpha-ketoglutarate. Indian journal of experimental biology 2010, 48(7):731–6.
464. Bienholz A. et al.: Adverse effects of alpha-ketoglutarate/ malate in a rat model of acute kidney injury. American journal of physiology Renal physiology 2012, 303(1):F56–63.
465. Coudray-Lucas C. et al.: Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls. Critical care medicine 2000, 28(6):1772–6.
466. Donati L. et al.: Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients. Clinical nutrition 1999, 18(5):307–11.
467. De Bandt J.P. et al.: A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients. The Journal of nutrition 1998, 128(3):563–9.
468. Campbell B. et al.: Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men. Nutrition 2006, 22(9):872–81.
469. Wax B. et al.: Acute L-arginine alpha ketoglutarate supplementation fails to improve muscular performance in resistance trained and untrained men. Journal of the International Society of Sports Nutrition 2012, 9(1):17.
470. Greer B.K., Jones B.T.: Acute arginine supplementation fails to improve muscle endurance or affect blood pressure responses to resistance training. Journal of strength and conditioning research / National Strength & Conditioning Association 2011, 25(7):1789–94.
471. Karsegard V.L. et al.: L-ornithine alpha-ketoglutarate in HIV infection: effects on muscle, gastrointestinal, and immune functions. Nutrition 2004, 20(6):515–20.
472. Young C. et al.: Hemorrhagic stroke in young healthy male following use of sports supplement Jack3d. Military medicine 2012, 177(12):1450–4.
473. Prosser J.M. et al.: Adverse effects associated with arginine alpha-ketoglutarate containing supplements. Human & experimental toxicology 2009, 28(5):259–62.
474. Randhawa S. et al.: Anterior segment complications of a nutritional supplement. Journal of cataract and refractive surgery 2007, 33(5):918–20.
475. Chen W. et al.: Anthocyanin-rich purple wheat prolongs the life span of Caenorhabditis elegans probably by activating the DAF-16/FOXO transcription factor. J Agric Food Chem 2013, 61(12):3047–53.
476. Leenders M. et al.: Fruit and vegetable intake and causespecific mortality in the EPIC study. Eur J Epidemiol 2014, 29(9):639–52.
477. Pierpaoli W., Regelson W.: Pineal control of aging: effect of melatonin and pineal grafting on aging mice. Proc Natl Acad Sci USA 1994, 91(2):787–91.
478. Anisimov V.N. et al.: Melatonin as antioxidant, geroprotector and anticarcinogen. Biochim Biophys Acta 2006, 1757(5–6): 573–89.
479. Bubenik G.A., Konturek S.J.: Melatonin and aging: prospects for human treatment. J Physiol Pharmacol 2011, 62(1):13–9.
480. Ayyadevara S. et al.: Remarkable longevity and stress resistance of nematode PI3K-null mutants. Aging Cell 2008, 7(1):13–22.
481. Bernardes de Jesus B. et al.: Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer. EMBO Mol Med 2012, 4(8):691–704.
482. Bivalacqua T.J. et al.: Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats. Am J Physiol Heart Circ Physiol 2003, 284(4):H1408–21.
483. Fayad R. et al.: Oral administration with papillomavirus pseudovirus encoding IL-2 fully restores mucosal and systemic immune responses to vaccinations in aged mice. J Immunol 2004, 173(4):2692–8.
484. Mouravlev A. et al.: Somatic gene transfer of cAMP response element-binding protein attenuates memory impairment in aging rats. Proc Natl Acad Sci USA 2006, 103(12):4705–10.
485. Nishida F. et al.: Restorative effect of intracerebroventricular insulin-like growth factor-I gene therapy on motor performance in aging rats. Neuroscience 2011, 177:195–206.
486. Schmidt U. et al.: In vivo gene transfer of parvalbumin improves diastolic function in aged rat hearts. Cardiovasc Res 2005, 66(2):318–23.
487. Wang H. et al.: Delayed angiogenesis in aging rats and therapeutic effect of adenoviral gene transfer of VEGF. Int J Mol Med 2004, 13(4):581–7.
488. Zhang G. et al.: Hypothalamic programming of systemic ageing involving IKK-beta, NF-kappaB and GnRH. Nature 2013,
497(7448):211–6.
489. Shen J. et al.: Transplantation of mesenchymal stem cells from young donors delays aging in mice. Sci Rep 2011, 1:67.
490. Villeda S.A. et al.: Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med 2014, 20(6):659–63.
491. Liang P. et al.: Human neural stem cells promote corticospinal axons regeneration and synapse reformation in injured spinal cord of rats. Chin Med J (Engl) 2006, 119(16):1331–8.
492. Barberi T. et al.: Neural subtype specification of fertilization and nuclear transfer embryonic stem cells and application in parkinsonian mice. Nat Biotechnol 2003, 21(10):1200–7.
493. Petit G.H. et al.: The future of cell therapies and brain repair: Parkinson’s disease leads the way. Neuropathol Appl Neurobiol 2014, 40(1):60–70.
494. D’Amour K.A. et al.: Production of pancreatic hormoneexpressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006, 24(11):1392–401.
495. Johannesson B. et al.: Toward beta cell replacement for diabetes. EMBO J 2015, 34(7):841–55.
496. Takahashi K., Yamanaka S.: Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126(4):663–76.
497. Zhong X.Y. et al.: Umbilical cord blood stem cells: what to expect. Ann NY Acad Sci 2010, 1205:17–22.
498. Xiao N. et al.: Co-transplantation of mesenchymal stromal cells and cord blood cells in treatment of diabetes. Cytotherapy 2013, 15(11):1374–84.
499. Wang D. et al.: Allogeneic mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus: 4 years of experience. Cell Transplant 2013, 22(12):2267–77.
500. Liu J. et al.: Clinical analysis of the treatment of spinal cord injury with umbilical cord mesenchymal stem cells. Cytotherapy 2013, 15(2):185–91.
501. Canavero S.: The “Gemini” spinal cord fusion protocol: Reloaded. Surg Neurol Int 2015, 6:18.
502. Behringer W. et al.: Survival without brain damage after clinical death of 60–120 mins in dogs using suspended animation by profound hypothermia. Crit Care Med 2003, 31(5):1523–31.
503. Balaban E.: Brain switching: studying evolutionary behavioral changes in the context of individual brain development. Int J Dev Biol 2005, 49(2–3):117–24.
504. Estrada V. et al.: Long-lasting significant functional improvement in chronic severe spinal cord injury following scar resection and polyethylene glycol implantation. Neurobiol Dis 2014, 67:165–79.
505. Breidenbach W.C. et al.: Outcomes of the first 2 American hand transplants at 8 and 6 years posttransplant. J Hand Surg Am 2008, 33(7):1039–47.
506. Minev I.R. et al.: Biomaterials. Electronic dura mater for longterm multimodal neural interfaces. Science 2015, 347(6218):159–63.
507. Soekadar S.R. et al.: An EEG/EOG-based hybrid brain-neural computer interaction (BNCI) system to control an exoskeleton for the paralyzed hand. Biomed Tech (Berl) 2015, 60(3):199–205.
508. Shih J.J. et al.: Brain-computer interfaces in medicine. Mayo Clin Proc 2012, 87(3):268–79.
509. Wissner-Gross A.D., Freer C.E.: Causal entropic forces. Phys Rev Lett 2013, 110(16):168702.
510. Pietschnig J., Voracek M.: One Century of Global IQ Gains: A Formal Meta-Analysis of the Flynn Effect (1909–2013). Perspect Psychol Sci 2015, 10(3):282–306.mm
511. Prescott V.E. et al: Transgenic expression of bean alpha-amylase inhibitor in peas results in altered structure and immunogenicity. J Agric Food Chem 2005,53(23):9023–30.
512. Genetically modified mush. Nat Biotechnol 2006, 24(1):2.
513. Lee R.Y. et al: Genetically modified alpha-amylase inhibitor peas are not specifically allergenic in mice. PLOS ONE 2013, 8(1):e52972.
514. Campbell P.M. et al: Comparison of the alpha-amylase inhibitor-1 from common bean (Phaseolus vulgaris) varieties and transgenic expression in other legumes – post-translational modifications and immunogenicity. J Agric Food Chem 2011, 59(11): 6047–54.
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